The Los Angeles Rams have dominated recent matchups versus the Arizona Cardinals, winning nine of the last 10 regular season games. The lone Cardinals victory came earlier this year thanks to a three-pronged rushing attack from Kyler Murray, James Conner and Chase Edmonds. They combined for 209 yards and could be popular NFL DFS picks for Monday Night Football, the final game of NFL Wild Card Weekend 2022.

Conner, a game-time decision, was a touchdown machine with 18 scores across 15 games, but that production could be hard to come by in the NFL playoffs 2022. Who should you target with your NFL DFS stacks and NFL DFS lineups on sites like DraftKings and FanDuel? Before making your NFL DFS picks for Monday Night Football and beyond, be sure to check out the NFL DFS advice, strategy and projections from SportsLine daily Fantasy expert Mike McClure.

McClure is a legendary professional DFS player with almost $2 million in career winnings. His methodology has led to enormous cashes on FanDuel and DraftKings. He took down two high-stakes tournaments on FanDuel in 2020 and recorded a pair top-10 finishes in tournaments with over 130,000 entrants on DraftKings. His lineups also finished inside the top 1 percent in more than a dozen other tournaments last season.

He uses a powerful prediction model that simulates every snap of NFL action, taking factors such as matchups, statistical trends and injuries into account. This allows him to find the best NFL DFS values that he shares only with members at SportsLine.

Now, McClure has turned his attention to Rams vs. Cardinals and locked in his top daily Fantasy football picks. You can only see them by heading to SportsLine.

Top NFL DFS picks for Cardinals vs. Rams

One of McClure's top NFL DFS picks for Monday's action is Rams receiver Cooper Kupp, who became just the fourth player in the Super Bowl era to win the Receiving Triple Crown. In his fifth NFL season, Kupp led the NFL in receptions (145), receiving yards (1,947) and receiving touchdowns (16).

In two regular season games against Arizona, Kupp averaged nine grabs for 93.5 yards, scoring once. The Cardinals allowed a 100-yard receiver just three times all year, but Kupp was one of those in Week 14. Arizona has allowed 13 receiving TDs to opposing wide receivers in the last five weeks alone. As mentioned, no wideout does a better job of catching TD passes than Kupp, so he's a no-brainer for Monday Night Football.

Another part of McClure's optimal NFL DFS strategy includes rostering Cardinals quarterback Kyler Murray, who averaged 325.5 passing yards and 50 rushing yards in the two regular season games against the Rams. Murray finished the season as the No. 10 quarterback in Fantasy points despite missing three full games due to an ankle injury.

Murray has averaged 46 rushing yards over his last six games compared to just 18.4 yards over his first eight contests. Picking up yards with his legs and arm will come in handy against a Rams defense that allowed 54 rushing yards to Tyler Huntley in Week 17 and 316 passing yards to Jimmy Garoppolo in Week 18. Murray also enters Monday Night Football with three straight turnover-free games so he's only supplying positive production to NFL DFS lineups.

How to set NFL DFS lineups for Cardinals vs. Rams

McClure is also targeting an undervalued player who is set to explode for huge numbers on Monday. This pick could be the difference between winning your tournaments and cash games or going home with nothing. You can only see who it is here.

So who is Mike McClure putting in his optimal NFL DFS lineups for Rams vs. Cardinals in the 2022 NFL playoffs? Visit SportsLine now to see optimal NFL DFS picks, rankings, advice, and stacks, all from a daily Fantasy expert with nearly $2 million in winnings, and find out.