Pittsburgh's five-game unbeaten streak is a distant memory following consecutive losses to the Chargers and Bengals. The Steelers are now teetering on the edge of irrelevancy when it comes to the NFL playoff picture. On Sunday, ben Roethlisberger and company will host Baltimore during the Week 13 NFL schedule. The Ravens are 4.5-point road favorites in the latest Week 13 NFL odds at Caesars Sportsbook.

Baltimore currently holds a one-game lead over Cincinnati in the AFC North standings. The Bengals are three-point home favorites against the Chargers, one of the slimmest NFL spreads of the week. Should you back either of the AFC North favorites this week in your NFL bets? All of the Week 13 NFL lines are listed below, and SportsLine's advanced computer model has all the NFL betting advice and predictions you need to make the best Week 13 NFL picks now.

The model, which simulates every NFL game 10,000 times, is up almost $7,100 for $100 players on top-rated NFL picks since its inception six-plus years ago. The model enters Week 13 of the 2021 season on an incredible 131-94 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, it has turned its attention to the latest Week 13 NFL odds and locked in picks for every NFL matchup. Head here to see every pick.

Top Week 13 NFL predictions

One of the model's strongest Week 13 NFL picks is that the Colts (-10) cover the spread against the Texans with points to spare. The Colts had their three-game winning streak snapped in a loss to Tampa Bay last week, but they did not lose ground to Tennessee in the AFC South. Indianapolis has already dominated Houston once this season, picking up a 31-3 win at home in mid-October. The Colts have not lost consecutive games since September, so they have consistently bounced back.

Houston has only recorded one home victory this season and is coming off a 21-14 loss to the Jets last week. The Texans enter Week 13 as the lowest-scoring team in the NFL and have only covered the spread once in their last seven games against the Colts.

SportsLine's model projects a big day for Indianapolis quarterback Carson Wentz, who is expected to throw for 253 yards and two touchdowns. The Colts are covering the spread in more than 60 percent of simulations.

Another one of the model's Week 13 NFL predictions: The Broncos (+9.5) cover against the Chiefs at Arrowhead. It's the third-largest spread of the week, per the Week 13 NFL Vegas odds at Caesars Sportsbook, and SportsLine's model sees an opportunity for anyone willing to take a large underdog. Kansas City has found itself again after early season struggles, but this game will test how potent the Chiefs really are.

The Broncos may have traded away Von Miller, but their defense has still held opponents under 400 total yards in their last four games. Quarterback Teddy Bridgewater has been cooking up a strong season that has supplied the team with enough competent play to win games. SportsLine's model projects him to get an assist from running backs Melvin Gordon and Javonte Williams, both of whom the model projects to get 60 yards on five yards per carry. SportsLine's simulations have Denver covering the spread well over 60 percent of the time.

How to make Week 13 NFL picks

The model has also made the call on who wins and covers in every other game on the Week 13 NFL schedule, and it's calling for a Super Bowl contender to go down hard. You can only get every pick for every game at SportsLine.

So which NFL picks can you make with confidence, and which Super Bowl contender goes down hard? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned almost $7,100 since its inception, and find out.

Week 13 NFL odds, spreads, lines

Sunday, Dec. 5

Vikings at Lions (+7.5, 46.5)

Cardinals at Bears (+7.5, 42.5)

Buccaneers at Falcons (+10.5, 50.5)

Colts at Texans (+10, 44.5)

Eagles at Jets (+7, 45)

Chargers at Bengals (-3, 50)

Giants at Dolphins (-6, 39.5)

Washington at Raiders (-1.5, 49.5)

Jaguars at Rams (-13, 48)

Ravens at Steelers (+4.5, 44)

49ers at Seahawks (+3, 45.5)

Broncos at Chiefs (-9.5, 47)

Monday, Dec. 6

Patriots at Bills (-2.5, 42)