The No. 22 Marquette Golden Eagles will try to stretch their winning streak to seven when they square off against the Seton Hall Pirates in a Big East battle on Wednesday at the Prudential Center in Newark, N.J. Marquette (14-6, 6-3 Big East) has knocked off four ranked teams, including No. 11 Villanova, in its six-game winning streak. The streak is the program's longest since winning eight in a row in January 2019. Meanwhile, Seton Hall (12-6, 3-5) is looking to end a bit of a slide. The Pirates are 1-3 in their last four games, including a listless 84-63 loss to St. John's in their most recent outing.

Tip-off is set for 8:30 p.m. ET. The Pirates are favored by six points in the latest Marquette vs. Seton Hall odds, while the over-under for total points scored is 145. Before making any Seton Hall vs. Marquette picks, be sure to check out the college basketball predictions and betting advice from the SportsLine Projection Model.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. It enters Week 12 of the season with a 49-36 record on all top-rated college basketball picks, returning almost $700. Over the past five-plus years, the proprietary computer model has generated an impressive profit of $2,800 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Marquette vs. Seton Hall and locked in its picks and CBB predictions. You can visit SportsLine now to see the model's picks. Here are the college basketball odds and betting lines for Seton Hall vs. Marquette:

  • Marquette vs. Seton Hall spread: Seton Hall -6
  • Marquette vs. Seton Hall over-under: 145 points
  • Marquette vs. Seton Hall money line: Pirates -240, Golden Eagles +195
  • MARQ: Tyler Kolek ranks eighth in the nation in assists per game (6.5)
  • SH: Seton Hall averages 5.6 blocks per game, which ranks 16th in the country

Why Seton Hall can cover 

Seton Hall has the size to affect Marquette's shooting. The Pirates start Ike Obiagu, a 7-foot-2 center from Nigeria, and bring two 6-foot-10 bigs off the bench -- Tyrese Samuel and Tray Jackson -- to play big minutes. Led by Obiagu, Seton Hall averages 5.6 blocks per game, which ranks 16th in the country.

In addition, the Pirates are one of the best free throw shooting teams in the nation. They make 76.7 percent of their free throws, which ranks second in the Big East and 26th in Div. I. That bodes well against a Marquette team that commits fouls at a high rate (17.4 per game, 234th in the country.)

Why Marquette can cover

Marquette has been red-hot from the field during its winning streak. Over the last six games, Shaka Smart's club has shot 50.0 percent from the field, including 42.7 percent on 3-pointers. Prior to that, the Golden Eagles had shot 42.9 percent from the field and 31.5 percent from beyond the 3-point arc.

One of the team's hottest players has been Justin Lewis. In the last two games, the 6-foot-7 redshirt freshman led Marquette to a 57-54 victory at No. 11 Villanova and a 75-64 win against No. 20 Xavier. At Villanova, he scored a team-high 21 points, including a 3-pointer with 11.9 seconds left that was the game-winning basket. In the win over Xavier, he had game highs in points (20) and rebounds (13).

How to make Seton Hall vs. Marquette picks

SportsLine's model is leaning under on the total, projecting 143 combined points. It has also generated an against-the-spread pick that cashes in well over 50 percent of simulations. You can only get the model's picks at SportsLine

So who wins Marquette vs. Seton Hall? And which side of the spread hits in well over 50 percent of simulations? Visit SportsLine now to see which side of the spread to jump on, all from the advanced model that is up $2,800 on its top-rated college basketball picks the last five years, and find out.