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The James Madison Dukes will take on the Virginia Cavaliers at 6:30 p.m. ET on Tuesday at the Atlantic Union Bank Center. James Madison is 7-2 overall and 4-0 at home, while Virginia is 6-3 overall and 0-1 on the road. The programs last met in 2019 with Virginia winning 65-34 as a 24.5-point favorite, but both rosters have changed dramatically since that matchup.

The Cavaliers are favored by 4.5 points in the latest James Madison vs. Virginia odds from Caesars Sportsbook and the over-under is set at 124. Before entering any Virginia vs. James Madison picks, you'll want to see the college basketball predictions from the model at SportsLine.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of over $2,200 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on James Madison vs. Virginia. You can head to SportsLine to see its picks. Here are several college basketball odds for Virginia vs. James Madison:

  • James Madison vs. Virginia spread: Virginia -4.5
  • James Madison vs. Virginia over-under: 124 points
Featured Game | James Madison Dukes vs. Virginia Cavaliers

What you need to know about James Madison

The Dukes took their matchup at home last Thursday with ease, bagging a 96-54 victory over the Eastern Mennonite Royals. Takal Molson had a monster game off the bench in the victory with 25 points, 11 rebounds, four assists and three steals. Vado Morse had 15 points while Alonzo Sule chipped in with 12 points and eight rebounds.

The James Madison defense has been extremely disruptive so far this season, forcing an average of 19.1 turnovers per game and ranking fourth nationally with 11.8 steals per contest. The Dukes' ability to interrupt the flow of the Cavaliers' offense and create transition opportunities should be key.

What you need to know about Virginia

Meanwhile, Virginia skirted by the Pittsburgh Panthers 57-56 this past Friday thanks to a clutch 16-foot fadeaway jumper from the corner by forward Jayden Gardner as the clock expired. Gardner had a solid day in the win, picking up 15 points along with five rebounds.

With so much roster turnover from last year, Tony Bennett's squad is still trying to find its new identity, but the Cavaliers are playing stingy defense per usual for their head coach. Virginia is giving up 56.2 points per game this season (10th in the nation) and is only allowing opponents to shoot 39.1 percent from the floor.

How to make James Madison vs. Virginia picks

The model is leaning over on the total and it's also generated a point-spread pick that is hitting in almost 70 percent of simulations. You can only see the pick at SportsLine.

So who wins Virginia vs. James Madison? And which side of the spread hits nearly 70 percent of the time? Visit SportsLine now to find out, all from the red-hot model that has crushed its college basketball picks.