No. 24 Clemson and South Carolina will put their respective three-game winning streaks on the line when they square off on Saturday night. The Tigers (7-4) are not in the hunt for the ACC title, but they have won three straight games to put themselves in line for a decent bowl bid. Their latest win was a 31-20 win over then-No. 20 North Carolina last week, covering the 7.5-point spread in the process. South Carolina (5-6) has won three straight games as well, beating Kentucky in a 17-14 nailbiter last week. 

Kickoff is set for 7:30 p.m. ET on Saturday at Williams-Brice Stadium. Clemson is favored by 7.5 points in the latest South Carolina vs. Clemson odds, while the over/under is 49 points, per SportsLine consensus. Before entering any Clemson vs. South Carolina picks, you'll want to see the college football predictions from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Since its inception, it has generated a strong profit of well over $2,000 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

The model has set its sights on Clemson-South Carolina. You can head to SportsLine to see its picks. Here are several college football betting lines for the game:

  • South Carolina vs. Clemson spread: Clemson -7.5
  • South Carolina vs. Clemson over/under: 49 points
  • South Carolina vs. Clemson money line: Clemson -310, South Carolina +247
  • South Carolina vs. Clemson picks: See picks here
  • South Carolina vs. Clemson live stream: fubo (try for free)

Why South Carolina can cover

South Carolina is playing its best football of the season, rattling off three consecutive wins at home to get within one victory of bowl eligibility. The Gamecocks have won two of those games by double digits, and they also won a close contest against Kentucky as 2-point favorites last week. Quarterback Spencer Rattler has thrown for nearly 1,000 total yards and seven touchdowns during that stretch. 

The Gamecocks are 5-1 at home this season, and they took down Clemson on the road last season. Star wide receiver Antwane Wells Jr. practiced last week and could play on Saturday, which would be his first game action since Week 3. South Carolina has been excellent in the final week of the regular season, covering the spread at an 11-4 clip in its last 15 games in Week 13. 

Why Clemson can cover

While Clemson might not be playing in the ACC title game this season, the Tigers still have plenty of motivation heading into this contest. They lost to South Carolina in a stunning upset, snapping a seven-game winning streak in the series. Clemson has won three straight games this season, beating then-No. 15 Notre Dame and then-No. 20 North Carolina during that stretch. 

Sophomore quarterback Cade Klubnik threw for 219 yards and a touchdown last week, while running back Will Shipley rushed for 126 yards and a score. Shipley has combined with running mate Phil Mafah for more than 1,500 rushing yards this season, with both backs averaging more than five yards per carry. Clemson has covered the spread in four of the last six meetings between these teams. See which team to pick here. 

How to make South Carolina vs. Clemson picks

The model has simulated Clemson vs. South Carolina 10,000 times and the results are in. The model is leaning Under, and it's also generated a point-spread pick that is hitting in well over 60% of simulations. You can only see the pick at SportsLine.

So who wins South Carolina vs. Clemson, and which side of the spread hits well over 60% of the time? Visit SportsLine now to see which side of the Clemson vs. South Carolina spread to jump on, all from the advanced computer model that's up well over $2,000 on its top-rated college football spread picks since its inception, and find out.