Patrick Mahomes and the Kansas City Chiefs will battle Joe Burrow and the Cincinnati Bengals on Sunday. The Chiefs are riding a five-game winning streak and are eager to avenge last season's loss in the AFC Championship Game. Mahomes is the favorite to win the NFL MVP award at Caesars Sportsbook with -170 odds. The Bengals, meanwhile, have won three in a row and five of their last six. They've largely played themselves out of an early-season malaise and could now get top receiver Ja'Marr Chase back. The Chiefs are two-point favorites in the Week 13 NFL odds at Caesars Sportsbook. Which Week 13 NFL lines should you target with your Week 13 NFL bets? Before you make any Week 13 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine's proven computer model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 13 of the 2022 NFL season on an incredible 155-110 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has locked in five confident NFL best bets for Week 13. If you successfully parlay its picks, you'd be looking at a massive payout of around 25-1. You can only see the model's Week 13 NFL picks at SportsLine.

Top Week 13 NFL picks

After simulating every game 10,000 times, the model is high on the San Francisco 49ers (-3.5) to cover against the Miami Dolphins. The rugged San Francisco defense will be tested against one of the best offenses in the NFL.

The Dolphins are averaging 386.7 yards of offense per game, and that includes a stretch played without Tua Tagovailoa at quarterback. The 49ers, however, are allowing just 281.7 yards per game, the lowest number in the league. The unstoppable object and the immovable force will collide head-on, which makes San Francisco's home field advantage and the fact that the Dolphins will be flying cross-country for the game important. That is one reason the 49ers are covering the spread in over 50% of simulations. See which other NFL parlay picks to make here.

How to make Week 13 NFL parlays

The model also jumped on four other NFL matchups where it says the line is way off, including a pair of underdogs that are projected to win outright. You can only see the model's NFL Week 13 best bets and parlay at SportsLine

What are the model's top Week 13 NFL picks? And which other NFL matchups should you target for a strong 25-1 payout? Visit SportsLine now to see the Week 13 NFL best bets from a model on a 155-110 run on its top-rated picks, and find out.