The No. 2 seed Iowa State Cyclones and the No. 7 seed Washington State Cougars collide in the second round of the 2024 NCAA Tournament on Saturday. A trip to the Sweet 16 to take on the winner of Illinois vs. Duquesne is on the line. Washington State has only made it that far once. Meanwhile, Iowa State has made it to the Sweet 16 six times overall.

Tipoff from the Chi Health Center Omaha is set for 6:10 p.m. ET. The Cyclones are 6.5-point favorites in the latest Washington State vs. Iowa State odds from SportsLine consensus, while the over/under for total points scored is 128. Before making any Iowa State vs. Washington State picks, be sure to see the college basketball predictions and betting advice from the SportsLine Projection Model.

The model simulates every Division I college basketball game 10,000 times. It enters the 2024 NCAA tournament on a 148-106 roll on all top-rated college basketball picks dating back to last season, returning more than $1,700 for $100 players. It also has a strong 29-19 (+810) record on top-rated spread picks this season. Anyone following has seen huge returns.

Now, the model has set its sights on Washington State vs. Iowa State and revealed its CBB picks and predictions. You can head to SportsLine now to see the model's picks. Here are several college basketball odds and trends for Iowa State vs. Washington State:

  • Washington State vs. Iowa State spread: Cyclones -6.5
  • Washington State vs. Iowa State over/under: 128 points  
  • Washington State vs. Iowa State money line: Cyclones -284, Cougars +229
  • ISU: Iowa State is 25-10 against the spread this season.   
  • WSU: Washington State is 18-15-1 against the spread this season.   
  • Washington State vs. Iowa State picks: See picks at SportsLine

Why Iowa State can cover

Freshman Milan Momcilovic generates plenty of offense for this squad. He is a catch-and-shoot threat, while also owning terrific range. Momcilovic averages 11.2 points, 3.2 rebounds and shoots 35% from beyond the arc. In Thursday's win over South Dakota State, Momcilovic notched 19 points and five rebounds.

Senior guard Curtis Jones is another athletic player for this squad. Jones comes off the bench and gives a spark offensively. He likes to get into the lane and uses his quickness to intercept passes. The Minnesota native averages 10.5 points, 2.9 rebounds and 1.5 steals per game. Jones had 11 points, three assists and two steals in his last game. See which team to pick here.

Why Washington State can cover

Freshman Myles Rice is a combo guard making an impact in his first season. Rice has a quick first step and gets by defenders on a regular basis. The South Carolina native logs 14.9 points, 3.1 rebounds and 3.9 assists per game. On Mar. 14 against Stanford, Rice tallied 14 points, six rebounds and six assists.

Senior forward Andrej Jakimovski does his damage on the perimeter. Jakimovski moves well without the ball and has a quick release. He logs 9.9 points, 5.5 rebounds and makes 1.9 3-pointers a game. He's scored in double figures in three of his last six matchups. In the Feb. 29 win over USC, Jakimovski had 18 points, five boards and knocked down four threes. See which team to pick here

How to make Washington State vs. Iowa State picks

SportsLine's model is leaning Over on the point total, projecting the teams to combine for 138 points. The model also says one side of the spread hits more than 60% of the time. You can only see the model's picks at SportsLine

So who wins Iowa State vs. Washington State, and which side of the spread hits more than 60% of the time? Visit SportsLine now to see which side of the Iowa State vs. Washington State spread you need to jump on, all from the model on a 148-106 roll on its top-rated college basketball picks, and find out.