No. 2 seed Duke and No. 7 seed Michigan State are each one win away from pitting legendary head coaches Mike Krzyzewski and Tom Izzo against each other in the second round of the 2022 NCAA Tournament bracket. The Blue Devils will need to take care of business against No. 15 seed Cal State Fullerton, while Michigan State needs a win over No. 10 seed Davidson. Izzo has gone 3-12 in his previous 15 matchups against Krzyzewski. Which team should you back in the 2022 March Madness bracket?

Other storylines to keep in mind when filling out your 2022 NCAA bracket include potential second-round matchups between No. 2 seed Auburn and No. 7 USC, along with No. 1 Baylor and No. 8 North Carolina. One upset could change the entire trajectory of the NCAA Tournament 2022. Before filling out any NCAA Tournament bracket 2022, be sure to see the 2022 March Madness bracket picks from the proven computer model at SportsLine.

SportsLine's advanced computer model absolutely crushed its March Madness picks last tournament, beating over 92 percent of all CBS Sports brackets for the second time in three years. The model also nailed a whopping three teams in the Final Four last year. 

It knows how to spot an upset as well. The same model has produced brackets that have nailed 17 first-round upsets by double-digit seeds. It also nailed some massive upsets last tournament, including predicting the championship game between Gonzaga and Baylor, and hit Houston's Midwest Region win even though the Cougars weren't the No. 1 seed.

There's simply no reason to rely on luck when there's proven technology to help you dominate your 2022 March Madness picks. Now, the model has simulated every possible matchup in the 2022 NCAA Tournament and revealed its optimal bracket. You can only see it over at SportsLine.

Top 2022 March Madness bracket picks

One team set to disrupt 2022 March Madness brackets, according to the model: No. 6 Alabama loses to No. 11 Notre Dame in the first round in the West Region. Sometimes having too long of a layoff heading into the NCAA Tournament is detrimental, giving their opponent an edge. Alabama has not played since losing to Vanderbilt in the second round of the SEC Tournament on March 10. Notre Dame will be loose and confident following its double-overtime win over Rutgers in Wednesday's First Four matchup.

The Crimson Tide are riding a three-game losing streak, including upset losses to Texas A&M and Vanderbilt. Guard Jahvon Quinerly has turned the ball over 19 times in his last four games, which does not bode well in the postseason. Notre Dame is in the top 25 in turnover rate, so the Fighting Irish are primed to knock off Alabama and shake up in Friday's West Region showdown.

Another team to back in your 2022 NCAA Tournament picks: The 10th-seeded Davidson Wildcats, who stun No. 7 Michigan State in the first round of the West Region. Davidson has struggled against teams from the Big Ten, winning just one of its last 10 meetings. However, the Wildcats will enter this matchup as one of the best shooting teams in the country. In fact, Davidson is knocking down 38.65 percent of its three-point attempts this season, the eighth-best mark in college basketball.

The Wildcats are also connecting on 48.14 percent of their field goals, which ranks 18th in the nation. Meanwhile, Michigan State has lost six of its last 10 games, one of the main reasons why SportsLine's model is backing Davidson to pull off the upset.

How to make 2022 NCAA Tournament bracket predictions

SportsLine's model also has one region where the No. 5 seed goes to the Elite Eight and the 14-seed delivers a shocking upset. Nailing those picks could literally make or break your bracket. With the model's proven track record of calling bracket-busting upsets, you'll want to see which stunners it is calling this year before locking in any bracket picks.

So who else makes a deep run in the NCAA Tournament 2022? Visit SportsLine now to see which region features a No. 5 seed in the Elite Eight and a 14-seed that delivers a massive shocker, plus see who wins every single game, all from the model that beat over 92 percent of bracket players two of the last three years.