UCLA made a surprising run to the Final Four a season ago as a No. 11 seed. The Bruins enter the 2022 NCAA Tournament bracket as a No. 4 seed in the East Region after going 25-7 and posting a 15-5 record in Pac-12 play. A Pac-12 team hasn't won a national championship since 1997, but the Bruins have all the tools needed to make another deep run in the 2022 March Madness bracket. Ahead of the 2022 NCAA basketball tournament, Johnny Juzang leads the Bruins in scoring, averaging 16.0 points per game.

Juzang was sensational in the NCAA Tournament a season ago, scoring 21.3 points per game, which included a 29-point outburst against Gonzaga in the Final Four. How far will Juzang and the Bruins advance in the East? Which double-digit seeds have the best chance at making a deep run in the March Madness 2022 bracket? Before you make your 2022 NCAA Tournament predictions, see the March Madness bracket picks from the proven computer model at SportsLine.

SportsLine's advanced computer model absolutely crushed its March Madness picks last tournament, beating over 92 percent of all CBS Sports brackets for the second time in three years. The model also nailed a whopping three teams in the Final Four last year.

It knows how to spot an upset as well. The same model has produced brackets that have nailed 17 first-round upsets by double-digit seeds. It also nailed some massive upsets last tournament, including predicting the championship game between Gonzaga and Baylor, and hit Houston's Midwest Region win even though the Cougars weren't the No. 1 seed. Getting those picks right could literally make or break your March Madness bracket.

Now, SportsLine's advanced computer model has simulated the entire NCAA Tournament 10,000 times to come up with the perfect 2022 NCAA Tournament bracket and find out which teams will pull off the biggest upsets. You shouldn't even think about making a pick without seeing what their model has to say.

Top 2022 March Madness bracket upset picks

One team set to pull off a shocking upset in 2022 March Madness brackets: No. 9 Memphis knocks off No. 8 Boise State in the West Region. The Tigers enter this matchup full of confidence after winning 12 of their last 14 games. Memphis features an athletic lineup that will try to exploit the mismatches against Boise State. The Tigers rank 21st in offensive rebounds per game (12.48), which will give Memphis multiple second-chance scoring opportunities.

Jalen Duren leads the Tigers on offense, averaging 12.2 points per game. The talented freshman is also recording 8.1 rebounds and 2.2 blocks and is expected to be heavily involved in Memphis' game plan against Boise State. The 6-foot-11 center is knocking down 62.6 percent of his field goals this season. He's also recorded a double-double in three of his last five outings. Plus, Memphis is 5-0 in its last five meetings against opponents from the Mountain West conference.

Another huge curveball in the West Region: No. 10 Davidson upsets No. 7 Michigan State. Davidson is led by MSU transfer Foster Loyer, who scored more points in his first year with the Wildcats than he had combined over three seasons in Lansing. Loyer averages 16.3 points per game and is one of the nation's premier shooters. He leads all Division I players in free throw percentage and ranks fourth in three-point percentage.

Loyer knows what Michigan State wants to do on both ends of the floor, and Tom Izzo likely wishes he still had the Michigan native in his rotation. The Spartans lack any scorers of Loyer's caliber, as he is one of four Davidson players averaging more points than any MSU player. Loyer's inside information on the Spartans should prove invaluable for the game's preparation, and that's one of the many reasons why the model favors the Wildcats.

How to make 2022 NCAA Tournament bracket predictions

SportsLine's model also says a No. 11 seed and a No. 5 seed make the Final Four. It also tells you which No. 12 and No. 10 seeds are a must-back. Nailing those picks could literally make or break your bracket. With the model's track record of calling bracket-busting upsets, you'll want to see which stunners it is calling this year before locking in any NCAA bracket picks.

So what's the optimal NCAA Tournament 2022 bracket? And which underdogs will shock college basketball? Visit SportsLine here to see which No. 11 and No. 5 seeds make the Final Four, plus which 12- and 10-seeds are a must-back, all from the model that's nailed 17 double-digit seed upsets in the first round.