No. 4 Cincinnati (11-0) and East Carolina (7-4) will battle it out in an AAC contest on Friday afternoon. These squads roll into this matchup with two of the better scoring offenses in the conference. Cincinnati is ranked first in the AAC with 40 points per game, while ECU is ranked fifth with 31.2 points per game. The Bearcats have punched their ticket to the AAC title game against Houston, but they'll be looking for a win and style points as they hope to hold down one of the four College Football Playoff spots.

Kickoff from Dowdy-Ficklen Stadium in Greenville, N.C. is set for 3:30 p.m. ET. The latest Cincinnati vs. East Carolina odds from Caesars Sportsbook list the Bearcats at -14, while the over-under for total points is set at 56.5, down two points from the opening line. Before locking in any ECU vs. Cincinnati picks, make sure you check out the college football predictions and betting advice from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,700 for $100 players on its top-rated college football picks against the spread. It also enters Week 13 of the 2021 season on a 39-25 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, the model has locked in on Cincinnati vs. ECU and just revealed its picks and CFB predictions. You can visit SportsLine now to see the model's picks. Here are the CFB odds and betting lines for ECU vs. Cincinnati:

  • Cincinnati vs. East Carolina spread: Cincinnati -14 
  • Cincinnati vs. East Carolina over-under: 56.5 points 
  • Cincinnati vs. East Carolina money line: East Carolina +425, Cincinnati -600 
  • CINN: Bearcats are 4-0 ATS vs. a team with a winning record  
  • ECU: Pirates are 5-0-1 ATS in their last 6 games as an underdog

Why Cincinnati can cover

The Bearcats have been playing sensational defense throughout the year. They are ranked sixth in the nation in scoring defense, allowing 16 points per game. Senior linebacker Joel Dublanko has been flying around for the Bearcats. He leads the team with 89 total tackles. Sophomore linebacker Deshawn Pace is tied for second on the team with 75 total tackles, while also snagging a team-high four interceptions.

Senior cornerback Coby Bryant has been exceptional for the Bearcats. He has recorded 34 total tackles, including 27 solo. Bryant is tied for sixth in the nation with 11 pass deflections while coming away with three interceptions. The Ohio native has also forced two fumbles and returned an interception back for a score. 

Why East Carolina can cover 

The Pirates head into this matchup with one of the top offenses in the conference. They are ranked second in the AAC at 447.5 total yards per game. They have a well-balanced attack that is headlined by junior quarterback Holton Ahlers and freshman running back Keaton Mitchell. Ahlers is third in the conference, averaging 264.3 passing yards per game. He has completed 63 percent of his passes for 2,898 and 17 passing touchdowns. The North Carolina native had his best game of the season against Navy, going 27-of-32 for a season-high 405 yards and three touchdowns.

Mitchell leads the Pirates with 157 carries for 1,077 yards with nine touchdowns. The Georgia native has rushed for more than 100 yards in four games this season. He had a monster performance against Tulane. He finished with 15 carries for a season-high 222 yards and two scores. Mitchell is also a receiving threat coming out the backfield, as he has 22 receptions and 253 receiving yards.

How to make Cincinnati vs. East Carolina picks

SportsLine's model is leaning under on the total, projecting 56 combined points. The model also says one side of the spread hits in 60 percent of simulations. You can only get the model's East Carolina vs. Cincinnati pick at SportsLine. 

So who wins Cincinnati vs. East Carolina? And which side of the spread hits in 60 percent of simulations? Visit SportsLine now to see which side of the spread you need to jump on, all from the model that has crushed its college football picks, and find out.