The 2022 Cadence Bank Houston Open will be the second-to-last PGA Tour stop of the calendar year and a talented field will descend upon Memorial Park Golf Course to hunt for FedEx Cup points before the holiday break. Three of the top 15 players in the Official World Golf Ranking are scheduled to be in the 2022 Houston Open field, highlighted by No. 2 Scottie Scheffler. The 26-year-old Texan spent 25 weeks at No. 1 this year and he's already had a win and a runner-up finish while playing in his home state in 2022.

Scheffler is coming off a T-3 finish at Mayakoba last week and he's listed as the 11-2 favorite in the 2022 Cadence Bank Houston Open odds from Caesars Sportsbook. Fellow top-15 players Sam Burns (12-1) and Tony Finau (16-1) will also be in the field and past Houston Open winner Russell Henley is at 25-1 in this week's PGA Tour odds coming off his win last week. Before locking in your 2022 Houston Open picks, be sure to see the golf predictions and projected leaderboard from the proven computer model at SportsLine.

SportsLine's proprietary model, built by DFS pro Mike McClure, has been red-hot since the PGA Tour resumed in June of 2020. In fact, the model is up over $9,500 on its best bets since the restart, nailing tournament after tournament.

McClure's model included J.T. Poston in its best bets to win the 2022 John Deere Classic. That bet hit at +5500, and for the entire tournament, McClure's best bets returned almost $1,100. At the 2022 Masters, McClure's model was all over Scottie Scheffler's first career major championship victory heading into the weekend.

In addition, McClure's best bets included Collin Morikawa winning outright at the 2021 Open Championship, even though he was listed as a massive 40-1 long shot. The model was also all over Jon Rahm's (10-1) first career major championship victory at the 2021 U.S. Open. Rahm was two strokes off the lead heading into the weekend, but the model still projected him as the winner.

This same model has also nailed a whopping eight majors entering the weekend. Anyone who has followed it has seen massive returns.

Now that the 2022 Cadence Bank Houston Open field is locked, SportsLine simulated the tournament 10,000 times, and the results were surprising. Head to SportsLine now to see the projected leaderboard.

Top 2022 Cadence Bank Houston Open predictions 

One major surprise the model is calling for at the 2022 Cadence Bank Houston Open: Finau, a four-time PGA Tour champion and one of the top favorites at 16-1, stumbles this week and doesn't even crack the top-five. Finau recorded two wins and seven top-10 finishes last season, but he's struggled in Houston in recent years. 

In fact, Finau missed the cut at this event last year after shooting a 73 in the second round. In addition, the 33-year-old missed the cut last week at Mayakoba and ranked 108th in overall putting average (1.610), 116th in one-putt percentage (39.08%) and 135th in total putting (246.8) last season, which doesn't bode well for his chances to win this week. He's not a strong pick to win it all and there are far better values in the Cadence Bank Houston Open 2022 field.

Another surprise: Hideki Matsuyama, a 22-1 longshot, makes a strong run at the title. Matsuyama has a much better chance to win it all than his odds imply, so he's a target for anyone looking for a huge payday. The 30-year-old Japanese superstar won the 2021 Masters and has seven other PGA Tour victories under his belt. He's currently No. 19 in the OWGR and is widely considered one of the best ball strikers on tour.

Matsuyama ranked sixth on the PGA Tour in strokes gained: approach (.711) in 2021-22 and he's been top 20 in that category in each of the last nine seasons. Matsuyama has previously played the Houston Open once, finishing T-2 in 2020. He hit nearly 70% of fairways and greens in regulation that week and Memorial Park is clearly a golf course that suits his eye well. See who else to pick here.

How to make 2022 Cadence Bank Houston Open picks

The model is also targeting three other golfers with odds of 22-1 or longer who will make surprising runs. Anyone who backs these longshots could hit it big. You can only see the model's PGA picks here.

So who will win the Cadence Bank Houston Open 2022? And which longshots stun the golfing world? Check out the 2022 Cadence Bank Houston Open odds below and then visit SportsLine to see the projected 2022 Houston Open leaderboard, all from the model that's nailed eight golf majors, including this year's Masters.

2022 Cadence Bank Houston Open odds, field

See full Houston Open 2022 picks, best bets, and predictions here.

Scottie Scheffler +550
Sam Burns +1200
Tony Finau +1600 
Aaron Wise +1600
Taylor Montgomery +2000 
Maverick McNealy +2000
Hideki Matsuyama +2200
Russell Henley +2500
Jason Day +3000
Denny McCarthy +3500
Sahith Theegala +4000
Matthew NeSmith +4000
Andrew Putnam +4000
Joel Dahmen +4500
Keith Mitchell +5000
Emiliano Grillo +5000
Davis Riley +5000
Taylor Pendrith +5000
Alex Noren +5000
Adam Hadwin +5000
Taylor Moore +5000
Si-Woo Kim +5000
Sebastian Munoz +6500
Patrick Rodgers +6500
Mackenzie Hughes +6500
Dean Burmester +6500
Alex Smalley +6500
Sepp Straka +8000
Lee Hodges +8000
Justin Lower +8000
Wyndham Clark +8000
Will Gordon +8000
Greyson Sigg +8000
Harris English +8000
Adam Schenk +8000
Ryan Palmer +10000
Robby Shelton +10000
Nick Taylor +10000
Luke List +10000
Justin Suh +10000
Justin Rose +10000
Francesco Molinari +10000
Davis Thompson +10000
Cameron Champ +10000
Brandon Wu +10000
Brendan Steele +10000
Beau Hossler +10000
Stephan Jagger +10000
Adam Long +10000
Aaron Rai +10000