A long-dormant rivalry is renewed Tuesday night as part of a loaded 15-game MLB schedule, with the New York Mets visiting the Astros for a brief interleague series. The teams, once NL rivals who met in a memorable 1986 NLCS, will face off twice in Houston before playing two more games next week in New York. Both teams are in first place in their divisions, and they are among the favorites to win the World Series. Meanwhile, the Yankees also are in first place and continue their series with AL East rival Tampa Bay as part of tonight's slate. The Yankees are a +450 second favorite behind the Dodgers (+420) in the latest World Series futures odds from Caesars Sportsbook, while the Astros (+700) and Mets (+750) also are top contenders.

First pitch in the Mets vs. Astros series is set for 8:10 p.m. ET. Caesars lists Houston as a -140 favorite on the money line, with New York a +120 underdog and the Over/Under for total runs set at nine. The Yankees are a -160 favorite in the Yankees vs. Rays matchup at 7:10 p.m. ET. The large slate provides plenty of opportunities for wagers, and you can cash in huge if you combine favorite picks into a parlay. Before you make your Tuesday MLB picks or parlays, be sure to check out the MLB predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times and it is off to a strong start to the 2022 season. It's on a 56-47 roll on top-rated MLB money-line picks through 11 weeks. Anyone who has followed it has seen profitable returns.

Now, the model has locked in four confident MLB best bets for Tuesday. They all involve games at 8:05 p.m. ET or later, so there's still time to get these MLB picks in. If you successfully parlay the picks, you'd be looking at a payout of more than 13-1. You can see the model's MLB picks for Tuesday only at SportsLine. 

Top MLB picks today

The model has one pick for the parlay that is hitting in nearly 70 percent of simulations, and that is San Diego (-140) beating Arizona at 9:40 p.m. ET (see tickets at StubHub). San Diego has won four of the five meetings this season. That includes Monday's 4-1 win, when the Padres got home runs from Jake Cronenworth and Trent Grisham. Star Manny Machado was out, and likely will be again Tuesday, but San Diego has the bats to fill in.

Luke Voit (nine homers), Jurickson Profar (eight), Cronenworth (seven) and Grisham (six) all have power, and Cronenworth also has 18 doubles and 41 RBI. Meanwhile, Arizona has the second-worst batting average in the major leagues at .217, and scheduled Padres starter Sean Manaea mowed down the Diamondbacks earlier this year. The left-hander held Arizona without a hit over seven innings and struck out seven in a 3-0 Padres win back in April.

Featured Game | San Diego Padres vs. Arizona Diamondbacks

How to make MLB parlays for Tuesday

The model has locked in three other best bets for Tuesday, including two more confident money line plays that would pay plus money. You can only see the model's MLB parlay picks and best bets for Tuesday at SportsLine.

What MLB picks should you target for a parlay offering a payout of more than 13-1? And which underdogs with excellent value are must-backs? Visit SportsLine now to see the MLB best bets for Tuesday from the model on a 56-47 roll on top-rated MLB money-line picks, and find out.