The Denver Nuggets look to take one step closer to locking up the No. 1 seed in the Western Conference playoff bracket when they take on the San Antonio Spurs on Friday at the Frost Bank Center in San Antonio. San Antonio is 20-60 overall and 10-29 at home, while Denver is 56-24 overall and 23-16 on the road. The Nuggets have won three straight and are coming off a massive 116-107 win over the Minnesota Timberwolves. The Spurs are looking to bounce back from a 127-89 loss to the Oklahoma City Thunder. The Spurs will be without Keldon Johnson (foot). Nikola Jokic (hip), Jamal Murray (knee), Aaron Gordon (foot), Michael Porter Jr. (quad), and Kentavious Caldwell-Pope (shoulder) are all probable for Denver. 

Tipoff is at 8 p.m. ET. The Nuggets are favored by 13 points in the latest Spurs vs. Nuggets odds, and the over/under is 222.5 points. Before making any Spurs vs. Nuggets picks, you'll want to see the NBA predictions and betting advice from the proven computer simulation model at SportsLine.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in profit for $100 players on its top-rated NBA picks over the past five-plus seasons. The model enters Week 23 of the 2023-24 NBA season on a sizzling 81-55 roll on all top-rated NBA picks this season, returning more than $2,300. Anyone following it has seen huge returns.

The model has set its sights on Nuggets vs. Spurs and just locked in its picks and NBA predictions. You can head to SportsLine now to see the model's picks. Here are several NBA odds and betting lines for the game:

  • Spurs vs. Nuggets spread: Spurs +13
  • Spurs vs. Nuggets over/under: 222.5 points
  • Spurs vs. Nuggets money line: Spurs: +565, Nuggets: -833
  • Spurs vs. Nuggets picks: See picks here

What you need to know about the Nuggets

The Nuggets notched a huge 116-107 win over the Timberwolves on Wednesday, and now control their own destiny when it comes to seeding in the Western Conference playoffs. Nikola Jokic continued his habit of posting crazy stat lines, dropping a double-double on 41 points and 11 rebounds. Michael Porter Jr. added 18 points and eight rebounds in the win.

Jokic has been the best player in the NBA this season, and will likely take home his third career MVP award. He enters Friday averaging 26.6 points, 9.0 assists, and 12.4 rebounds per game. Denver is 16-22-1 against the spread in road games this season. See which team to pick here.

What you need to know about the Spurs

Meanwhile, the Spurs gave up the first points and the most points on Wednesday. They took a serious blow against the Thunder, falling 127-89. San Antonio was in a tough position after the first half, with the score already sitting at 68-35.

Zach Collins was the top performer for the Spurs in the loss, scoring 20 points to go with seven rebounds, two assists, and two blocks. Rookie sensation Victor Wembanyama had the night off on Wednesday, but is expected to play against the Nuggets. The likely NBA Rookie of the Year is averaging 21.3 points, 10.6 rebounds, 3.8 assists, and 3.6 blocks per game. See which team to pick here

How to make Spurs vs. Nuggets picks

The model has simulated Spurs vs. Nuggets 10,000 times and the results are in. We can tell you that the model is leaning Under on the point total, and it's also generated a point-spread pick that is hitting in almost 70% of simulations. You can only see the model's pick at SportsLine.

So who wins Nuggets vs. Spurs, and which side of the spread hits almost 70% of the time? Visit SportsLine now to see which side of the Spurs vs. Nuggets spread you need to jump on Friday, all from the model on an 83-58 roll on all top-rated NBA picks this season, and find out.