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The No. 10 seed Miami Hurricanes and the No. 11 seed Iowa State Cyclones will both be looking to extend their surprising runs in the 2022 NCAA Tournament on Friday night. The Hurricanes booked their spot in the Sweet 16 with an upset win over Auburn, while the Cyclones knocked off Wisconsin in the second round of March Madness. Iowa State held the Badgers to a 2 of 22 effort from beyond the arc.

Tipoff is set for 9:59 p.m. ET on Friday at the United Center. Caesars Sportsbook lists the Hurricanes as three-point favorites in the latest Miami vs. Iowa State odds. The total for points scored is listed at 131.5, down 1.5 points from the opening line. Before making any Iowa State vs. Miami picks, be sure to check out the college basketball predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of over $1,300 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Miami vs. Iowa State and revealed its coveted picks and predictions for the NCAA Tournament 2022. You can head to SportsLine to see all of the model's college basketball picks. Here are several college basketball odds and trends for Iowa State vs. Miami:

  • Iowa State vs. Miami point spread: Miami -3
  • Iowa State vs. Miami over-under total: 131.5 points
  • Iowa State vs. Miami: money line: Miami -170, Iowa State +145
  • ISU: The Cyclones are 6-1 against the spread in neutral-site games as underdogs
  • MIA: The Hurricanes are 3-0-1 ATS in their last four games against opponents with winning records

Why Miami can cover

Miami is built to do well in the postseason, as it is led by several veteran guards. The Hurricanes have four players scoring in double figures, topped by Kameron McGusty's 17.5 points per game. They have the sixth-best turnover rate in college basketball, so they are not going to beat themselves on Friday night.

Iowa State was able to get past Wisconsin last weekend, despite shooting just 34.5 percent from the floor. The Cyclones have struggled on the offensive end of the court all season, which is going to catch up with them in this matchup. Miami has covered the spread in five of its last six games-Iowa State is 2-11 in its last 13 games in March. 

Why Iowa State can cover

The Cyclones are comfortable as underdogs. They were unanimously picked to finish last in the rugged Big 12 in a pre-season coaches' poll, which seemed logical considering they were coming off a two-win season, had a roster that didn't inspire fear from many opponents and were transitioning to first-year coach in T.J. Otzelberger. 

Moreover, some believed Iowa State didn't deserve one of the coveted at-large bids for the NCAA Tournament after it stumbled to three consecutive lopsided defeats ahead of Selection Sunday. This week, Otzelberger told the media that the team is still embracing its underdog status as Miami is a slight betting favorite and the Cyclones have another opportunity to prove doubters wrong.

"Our guys have been the chip on their shoulder, the underdog, the group that's been doubted," Otzelberger said. "It's hard to be unanimously picked last in your league, I would think. I don't know how often that happens. I don't think there can be anybody that's more of an underdog, more of a chip on their shoulder, more to prove, more of an us-against-the-world mentality." 

How to make Iowa State vs. Miami picks

SportsLine's model is leaning over on the point total, projecting the teams to combine for 141 points. The model also says one side of the spread hits well over 50 percent of the time. You can only see the model's pick at SportsLine.

So who wins Miami vs. Iowa State? And which side of the spread hits well over 50 percent of the time? Visit SportsLine now to find out which side of the spread you need to jump on, all from the model that has crushed its college basketball picks, and find out.