NFL: Indianapolis Colts at Jacksonville Jaguars
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The 2020 NFL season has flown by, as we are now entering Week 10 of action. Injuries have certainly derailed the progress of some would-be contenders, and oftentimes, remaining healthy down the stretch is a key attribute of Super Bowl champions. We certainly have plenty of players banged up this week, and the status of several stars for this Sunday is currently up in the air. 

Below, we will break down all the important injury information you need to know coming out of the NFL on Wednesday. Additionally, we will break down the final injury reports from the Indianapolis Colts and Tennessee Titans, as they are set to kick off Week 10 on Thursday evening. 

All NFL odds courtesy of William Hill Sportsbook. 

Colts at Titans (-2)

  • Colts: TE Jack Doyle (concussion) OUT, TE Mo Alie-Cox (knee) QUESTIONABLE
  • Titans: DB Adoree' Jackson (knee), TE MyCole Pruitt (Knee, ankle), WR Adam Humphries (concussion), DB Dane Cruikshank (groin) OUT

The Colts won't have Doyle on Thursday night, but they should have Alie-Cox. While he missed practice on Monday, he was a full participant on Wednesday, which should give him a good chance to suit up in this important AFC South showdown. Additionally, star wide receiver T.Y. Hilton was a full participant all week with a groin injury, so he's set to return to action tomorrow night. With Tennessee, continues to be in concussion protocol and will miss his second-straight game. While A.J. Brown (knee) was held out of practice on Monday, he practiced fully on Tuesday and Wednesday and carries no injury designation heading into Thursday Night Football. Corey Davis missed practice on Wednesday after the tragic death of his brother, who was battling cancer. 

Wednesday practice reports

Eagles (-3) at Giants

The Eagles are getting some offensive reinforcements as wide receiver Alshon Jeffery (calf) and running back Miles Sanders (knee) were able to practice. Jeffery was a full participant and Sanders was limited. Tackle Lane Johnson (ankle) was also limited. Defensive tackle Fletcher Cox was the lone player to not practice for Philadelphia, but the team says he was given a rest day. Running back Devonta Freeman (ankle), wide receiver Sterling Shepard (toe/hip) and tight end Kaden Smith (concussion) were all limited participants in Wednesday's practice session for the Giants. Cornerback Logan Ryan and defensive lineman Leonard Williams were absent, but appear to have been given rest days.

Buccaneers (-5.5) at Panthers

Rob Gronkowski was the lone Buccaneer to miss practice on Wednesday, but the team says it was not injury related. Ali Marpet (concussion), Lavonte David (knee), Scotty Miller (hip, groin) and Chris Godwin (finger) were among those limited. The big news coming out of Carolina on Wednesday is that star running back Christian McCaffrey will not play on Sunday, and could potentially be out longer due to a shoulder injury he suffered against the Chiefs. He was not at practice on Wednesday and will receive a second opinion on the injury. Offensive tackle Russell Okung also sat out with a calf injury and safety Jeremy Chinn was limited with a knee injury. In good news for the Panthers, defensive end Yetur Gross-Matos was a full participant with an ankle injury, as was cornerback Donte Jackson with a toe injury. 

Jaguars at Packers (-13)

Gardner Minshew II continues to be sidelined from practice for the Jaguars after suffering multiple injuries in his right thumb. Even when he does return, head coach Doug Marrone has kept open the possibility of Jake Luton maintaining the starting job. Receiver Laviska Shenault (hamstring), guard Andrew Norwell (calf), and safety Josh Jones (chest) were among those limited. In Green Bay, the Packers saw running back Aaron Jones (calf) participate fully in practice, which is a positive development after his strong performance on Thursday night against the 49ers. Starting left tackle David Bakhtiari (chest) was also a full participant. Corner Jaire Alexander (concussion, hand), linebacker Za'Darius Smith (not injury related), and tackle Rick Wagner (knee) were among the Packers not practicing. 

Texans at Browns (-3)

David Johnson (concussion) headlined the four Texans not practicing to begin the week. The veteran back is joined by linebacker Dylan Cole (back), guard Senio Kelemente (concussion) and defensive end Charles Omenihu (hamstring). If Johnson cannot play in Week 10, Duke Johnson would see a significant boost in snaps. The Browns, meanwhile, had perfect attendance at practice. Tight end Austin Hooper (abdomen) was a full participant, as was receiver Jarvis Landry (hip). The Browns also activated Baker Mayfield from the reserve/COVID-19 list. 

Bills at Cardinals (-2)

Buffalo began the week of practice without seven players, including corner Tre'Davious White (ankle) along with guards Brian Winters (knee) and Cody Ford (ankle). Receiver John Brown and defensive end Jerry Hughes were given veteran rest days. For Arizona, five starters did not practice on Wednesday, including receivers DeAndre Hopkins and Larry Fitzgerald. As it relates to those players, the team notes that their absences were not injury-related, which likely means they were given a veteran's day off. Running back Kenyan Drake (ankle) was limited after missing Week 9. 

Chargers at Dolphins (-2.5)

The Chargers had pass rusher Joey Bosa (concussion) back at practice on a limited basis Wednesday. Head coach Anthony Lynn noted that Bosa would take part in individual drills as he works toward full clearance. Running back Justin Jackson (knee) was held out of practice, but Lynn didn't officially rule him out of Week 10 yet. Tackle Bryan Bulaga (back) and guard Trai Turner (groin) were limited. The big news out of Miami is that wide receiver Preston Williams has been placed on IR, meaning that he will miss a minimum of three games. Williams suffered a foot injury after catching a nine-yard touchdown against the Cardinals in Week 9. Running back Matt Breida (hamstring), corner Jamal Perry (foot), and tight end Durham Smythe (concussion) were the only Dolphins limited. 

Broncos at Raiders (-5)

After turning in a Week 9 performance where he caught seven passes for a season-high 125 yards and a touchdown, the Broncos held rookie receiver Jerry Jeudy out of practice on Wednesday due to a shoulder injury. Meanwhile, safety Justin Simmons missed practice but it was not injury-related. Receiver Tim Patrick (hamstring) and tight end Noah Fant (ankle) were among the eight Broncos limited. Las Vegas had two key pieces of its offensive line out of practice on Wednesday. Starting center Rodney Hudson was held out, but it was not injury-related. Meanwhile, left tackle Kolton Miller missed Wednesday's session due to an ankle injury. Safety Johnathan Abram (groin) was limited.  

49ers at Saints (-9.5)

Kyle Shanahan effectively ruled out both Raheem Mostert and Tevin Coleman of Sunday's matchup against the Saints, telling reporters on Wednesday that he hopes the backs will be ready when to play following the Week 11 bye. Both did not practice on Wednesday along with linebacker Demetrius Flannigan-Fowles (hamstring), receiver Deebo Samuel (hamstring), receiver Trent Taylor (back) and corner K'Waun Williams (ankle). As for the Saints, every player on the active roster was present at practice. Quarterback Drew Brees (right shoulder) and receiver Michael Thomas (ankle, hamstring) were limited. While those injuries were known going into New Orleans' Week 9 game against the Bucs, right tackle Ryan Ramczyk (back) and center Erik McCoy (elbow) were two new additions to the injury report. 

Seahawks at Rams (-1.5)

The Seahawks are not starting the week off on the healthiest front. Running backs Chris Carson (foot) and Carlos Hyde (hamstring) were both sidelined on Wednesday along with starting center Ethan Pocic (concussion) and starting corners Quinton Dunbar (knee) and Shaquill Griffin (concussion, hamstring). Los Angeles had a smaller injury report with offensive lineman David Edwards (abdomen) and running back Darrell Henderson Jr. (quad) the only players missing from practice due to injury. Receiver Cooper Kupp was limited due to an oblique injury.  

Ravens (-7) at Patriots

The Ravens held out defensive end Calais Campbell (calf), linebacker Matthew Judon (calf), and Jimmy Smith (ankle) from practice on Wednesday while running back Mark Ingram (ankle) was a limited participant. Baltimore also activated corner Marlon Humphrey from the reserve/ COVID-19 list. New England's injury report continues to be one of the largest in the NFL as they had a total of 16 (!) players limited to begin the week. Running back Damien Harris was part of that group who was held back a bit in practice after suffering a chest injury that booted him from Monday's win against the Jets. N'Keal Harry (concussion) also returned to practice on a limited basis. The biggest development, however, is that star corner Stephon Gilmore, who has missed the past two games due to a knee injury, did not appear on the injury report, signaling that he's at full health.