While the pre-tournament focus at the 2021 U.S. Open focused on top-seeded players like Naomi Osaka and Ash Barty, the tournament has instead been a showcase for breakout stars. That is certainly the case in the women's final of the U.S. Open 2021 on Saturday, with Leylah Annie Fernandez squaring off against Emma Raducanu. Both teenagers are unseeded and have pulled off multiple upset victories over the course of the tournament. The festivities are set to begin at approximately 4 p.m. ET in Flushing Meadows at Arthur Ashe Stadium.

Raducanu is a -175 favorite (risk $175 to win $100) in the latest Fernandez vs. Raducanu odds from Caesars Sportsbook, with Fernandez getting +150 (risk $100 to win $140) as the underdog. Caesars set the over-under for total games at 21.5, with Raducanu favored by 2.5 games in the latest 2021 U.S. Open odds. Before making any 2021 U.S. Open picks, be sure to see the latest tennis predictions from SportsLine's Gavin Mair

A renowned women's tennis handicapper, Mair has cashed in huge at previous U.S. Open tournaments. He called Naomi Osaka (32-1) winning the 2018 U.S. Open and Bianca Andreescu (20-1) winning the 2019 U.S. Open. He also held a position on semifinalist Belinda Bencic (50-1) at the 2019 edition, and he nailed a +550 position on the second set of the 2021 Wimbledon final. Anyone who followed Mair's advice saw some huge returns. 

Now, Mair has locked in on the U.S. Open 2021 women's final matchup featuring Raducanu vs. Fernandez and revealed his best bets. Head to SportsLine to see them.

Top Raducanu vs. Fernandez predictions

The matchup between Raducanu and Fernandez is incredibly interesting for a number of reasons, but some stem from their youth and off-the-radar status entering the event. This is the first men's or women's major final in the Open Era to feature two unseeded players, and it is also the first match between teenagers in the U.S. Open final since 1999.

Fernandez has faced a more difficult path on the way to the final, beating former champions in Naomi Osaka and Angelique Kerber, as well as top-five seeds in Elina Svitolina and Aryna Sabalenka. This isn't the first time Fernandez will play for a high-level tournament win, as she won the Monterrey Open earlier this year, but this is her first major final and Raducanu is playing top-level tennis. 

Raducanu is the younger competitor at 18 years old, and she is the first qualifier to reach the U.S. Open final on either the men's or women's side since the Open Era began in 1968. She is also the first woman to come through qualifying to reach a final in the professional era, and Raducanu is the youngest grand-slam finalist since Maria Sharapova in 2004. Raducanu hasn't faced the gauntlet that Fernandez had to wade through, but she hasn't lost a set and has not lost more than four games in a single set in the entire tournament.

How to make Fernandez vs. Raducanu picks

Mair has studied this matchup in-depth and locked in two best bets, both of which return plus-money Head to SportsLine to see his best bets

Who wins Raducanu vs. Fernandez in the U.S. Open 2021 women's final? And which picks should you be all over? Visit SportsLine now to see Gavin Mair's best bets, all from a renowned tennis handicapper, and find out.