Tennis: Wimbledon
Susan Mullane / USA TODAY Sports

Roger Federer can move one step closer to an elusive 21st grand slam title when he faces Hubert Hurkacz on Wednesday in a 2021 Wimbledon quarterfinal at Centre Court of The All England Lawn Tennis Club. The 39-year-old Federer owns 20 grand slam titles, which is tied with Rafael Nadal for the most all-time. However, he hasn't won one since the 2018 Australian Open, a stretch of 11 straight slams without a victory. Federer will face Hurkacz on Wednesday, who upset Daniil Medvedev in a rain-delayed match on Tuesday. The match will follow the first quarterfinal between Novak Djokovic and Marton Fucsovics, which is set to begin at 8:30 a.m. ET. 

William Hill Sportsbook lists Federer as a -275 (risk $275 to win $100) favorite in the latest Federer vs. Hurkacz odds, with Hurkacz listed at +210 as the underdog. You can also pick whether Federer will cover the 3.5-game spread and how many games the match will last, among other options in the 2021 Wimbledon odds. Before making any Hurkacz vs. Federer picks, you need to see the Wimbledon 2021 predictions from famed tennis handicapper Sean Calvert.

Calvert is the renowned handicapper who called Stan Wawrinka winning the 2014 Australian Open at 60-1, the last Australian title won by someone other than Novak Djokovic or Federer. In 2019, Calvert took down a huge score on Dominic Thiem winning Indian Wells at 80-1. Anyone following his picks is way up.

Now, Calvert has scrutinized the latest Wimbledon 2021 odds and released his coveted best bet for Federer vs. Hurkacz. He's sharing his expert Wimbledon picks and analysis only at SportsLine.

Roger Federer vs. Hubert Hurkacz preview

No one has been better on the Wimbledon grass than Federer. In addition to his record eight singles titles, he has won a record 105 matches at Wimbledon. That is tied with clay court savant Rafael Nadal, who has won 105 matches at the French Open, for the most match victories at any grand slam.

The two players have faced each other once before. In 2019, Federer beat Hurkacz 6-4, 6-4 on the hard court at Indian Wells. In that match Federer took advantage of Hurkacz's second serve, winning 13 of 24 points, and converted on two of three break-point opportunities.

But Hurkacz enters Wednesday's match playing some of his best tennis. Earlier this year Hurkacz, 24, reached No. 16 in the world ranking, his best ever. That came after tournament victories in Miami and Delray Beach. He had won only once prior to this year.

On Tuesday, Hurkacz pulled off arguably the biggest upset of the fortnight -- and the biggest upset of his career -- taking down the second-seeded Medvedev in a match that was halted on Monday because of weather and forced to resume on Tuesday. Hurkacz dropped just four points in the fifth set behind his own serve while breaking Medvedev twice.

How to make Federer vs. Hurkacz picks

Calvert has revealed his full breakdown and has locked in a best bet that returns around 3-1. Be sure to check out Calvert's expert analysis before making your Wimbledon 2021 picks for the men's quarterfinals.

Who wins Federer vs Hurkacz in the 2021 Wimbledon men's quarterfinal? And what best bet do you need to be all over? Visit SportsLine now to see Sean Calvert's best bets for Hurkacz vs. Federer, all from the famed tennis handicapper who called Wawrinka winning the 2014 Australian Open at 60-1, and find out.