Tennis: US Open

World No. 5 Rafael Nadal has reached the quarterfinals of the Australian Open 13 previous times but went on to win just once. The sixth-seeded Spaniard hopes his quest for a second title continues when he takes on the 14th-seeded Denis Shapovalov in the quarterfinals of the 2022 Australian Open on Monday at 10 p.m. ET. Nadal, who won this tournament in 2009, advanced to the quarters for the sixth straight year by posting a grueling fourth-round victory over Adrian Mannarino 7-6 (16-14), 6-2, 6-2. Shapovalov reached the round of eight in Melbourne for the first time by upsetting the third-seeded Alexander Zverev 6-3, 7-6 (7-5), 6-3.

Nadal is a -300 favorite (risk $300 to win $100) in the latest 2022 Australian Open odds from Caesars Sportsbook, while Shapovalov is a +230 underdog (risk $100 to win $230). There are a number of other Nadal vs. Shapovalov bets you can make, including an over-under on total games played at 37.5 and who will win the first set (Shapovalov +160, Nadal -200). Before making any Shapovalov vs. Nadal picks, be sure to see the 2022 Australian Open predictions from internationally acclaimed tennis expert Sean Calvert.

Calvert is the elite tennis handicapper who called Stan Wawrinka winning the 2014 Australian Open at 60-1 – the last Australian title won by someone other than Djokovic or Federer. In 2019, Calvert took down a huge score on Dominic Thiem winning Indian Wells at 80-1, among many stunning calls.

And in 2021, he nailed both of his bets for the Wimbledon men's singles final: Djokovic to beat Matteo Berrettini three sets to one (+275) and Djokovic to win and both players to win a set (+130). Anyone following his picks is way up.

Now, Calvert has scrutinized the latest Australian Open 2022 odds and released his coveted best bets for Nadal vs. Shapovalov. He's sharing all his picks and analysis at SportsLine.

Rafael Nadal vs. Denis Shapovalov preview

Nadal is three victories away from making history as he looks to break a tie with Roger Federer and Novak Djokovic for most career men's grand slam singles titles (20). His 14 quarterfinal appearances in the Australian Open tie him with John Newcombe for second-most behind only Federer (15). Not including a walkover loss in the semifinals of the 2019 Rolex Paris Masters, the 35-year-old Nadal has won three of his four actual career meetings with Shapovalov, most recently in the third round in Rome last year.

Sidelined for a good portion of the 2021 season due to a foot injury, Nadal has lost just one set thus far in the Australian Open. He began 2022 by winning the Melbourne Summer Set earlier this month without dropping a set, wrapping up the title with a 7-6 (8-6), 6-3 triumph over Maxime Cressy.

Shapovalov unquestionably has earned his spot in the quarterfinals. The 22-year-old Canadian needed four sets to get past Laslo Djere in the first round and outlasted Soon Woo Kwon in five sets. He then won a hard-fought, four-set battle with No. 23 seed Reilly Opelka before knocking off reigning Olympic champion Zverev and has won five of seven tiebreakers in the tournament thus far.

After helping Canada win its first ATP Cup title earlier this month in Sydney, Shapovalov is making his third career quarterfinal appearance in a grand slam event. His first came in the 2019 U.S. Open, and he made it to the semifinals of Wimbledon last year but lost in straight sets to Djokovic. Shapovalov's only on-court victory over Nadal came in their first meeting in 2017, when he posted a shocking 3-6, 6-4, 7-6 (7-4) triumph in the third round of the Rogers Cup in Montreal.

How to make Nadal vs. Shapovalov picks 

Calvert has analyzed Shapovalo vs. Nadal and released his pick on the winner. He also has advice on what other 2022 Australian Open picks could pay off in a huge way. You need to see his picks and analysis before considering any 2022 Australian Open bets.

So who wins Nadal vs. Shapovalov in the 2022 Australian Open men's quarterfinal? And what pick could lead to a big return? Visit SportsLine now to see Sean Calvert's best bets for Shapovalov vs. Nadal, all from the renowned tennis expert who called Wawrinka winning this event at 60-1.