Tennis: US Open

Daniil Medvedev reached the final of last year's Australian Open by posting a straight-set victory over Stefanos Tsitsipas in the semis. If he wants another chance to capture the title, he'll have to get past the Greek again as they meet in the 2022 Australian Open men's semifinals on Friday at 3:30 a.m. ET. The second-seeded Medvedev lost the first two sets against Felix Auger-Aliassime in the quarters before rallying for a 6-7 (4-7), 3-6, 7-6 (7-2), 7-5, 6-4 victory, while No. 4 seed Tsitsipas cruised to a 6-3, 6-4, 6-2 triumph over Jannik Sinner.

Medvedev is a -275 favorite (risk $275 to win $100) in the latest 2022 Australian Open odds from Caesars Sportsbook, while Tsitsipas is a +210 underdog (risk $100 to win $210). There are a number of other Medvedev vs. Tsitsipas bets you can make, including an over-under on total games played at 39.5 and who will win the first set (Medvedev -175, Tsitsipas +135). Before making any Tsitsipas vs. Medvedev picks, be sure to see the 2022 Australian Open predictions from internationally acclaimed tennis expert Sean Calvert.

Calvert is the elite tennis handicapper who called Stan Wawrinka winning the 2014 Australian Open at 60-1 – the last Australian title won by someone other than Djokovic or Federer. In 2019, Calvert took down a huge score on Dominic Thiem winning Indian Wells at 80-1, among many stunning calls.

And in 2021, he nailed both of his bets for the Wimbledon men's singles final: Djokovic to beat Matteo Berrettini three sets to one (+275) and Djokovic to win and both players to win a set (+130). Anyone following his picks is way up.

Now, Calvert has scrutinized the latest Australian Open 2022 odds and released his coveted best bets for Medvedev vs. Tsitsipas. He's sharing all his picks and analysis at SportsLine.

Daniil Medvedev vs. Stefanos Tsitsipas preview

Medvedev is appearing in the semifinals for the fourth time in his last six grand slam tournaments. The 25-year-old is aiming for his second straight title after upsetting top seed Novak Djokovic 6-4, 6-4, 6-4 in last year's U.S. Open. Medvedev became the third Russian to win a major singles title and first since Marat Safin took the crown in the 2005 Australian Open.

Since Djokovic was denied the opportunity to capture his fourth consecutive Australian Open title due to much-publicized visa issues, Medvedev can earn the world No. 1 ranking by winning the championship. He also is attempting to become the first player in the Open era to win his first two career titles in back-to-back grand slam appearances. But he'll first have to get past Tsitsipas, who is 2-6 lifetime against Medvedev but has won two of their last three meetings.

The 23-year-old Tsitsipas is making his third semifinal appearance in Melbourne in four years. Before being defeated by Medvedev a year ago, he suffered a 2-6, 4-6, 0-6 loss against Rafael Nadal in 2019 after posting a stunning victory over Roger Federer two rounds earlier. Tsitsipas' only trip to a grand slam final came in the 2021 French Open, where he won the first two sets against Djokovic before falling 7-6 (8-6), 6-2, 3-6, 2-6, 4-6.

How to make Tsitsipas vs. Medvedev picks 

Calvert has analyzed Medvedev vs. Tsitsipas from every angle. He's locked in a strong pick on the winner, and has advice on another prop bet you should be all over. You need to see his picks and analysis before considering any 2022 Australian Open bets.

So what are the best bets you can make for the Medvedev vs. Tsitsipas in the 2022 Australian Open men's semifinal? And which prop pick has plenty of value? Visit SportsLine now to see Sean Calvert's best bets for Tsitsipas vs. Medvedev, all from the renowned tennis expert who called Wawrinka winning this event at 60-1.