A weakened draw could mean a big opportunity for Novak Djokovic or Rafael Nadal, or a huge chance for an upstart, when the 2022 Wimbledon men's single tournament begins Monday. The top two players in the world - No. 1 Daniil Medvedev and second-ranked Alexander Zverev -- are absent from the All England Club. That means Djokovic's path to a fourth straight Wimbledon title and a 21st Grand Slam crown will be a little easier. But Nadal, who has a record 22 Grand Slam titles and has won the past two, is always a threat to win another. Djokovic has won six times in London, and Nadal took the 2008 and 2010 titles, but there is still plenty of talent in the draw. Djokovic could have to go through Spanish phenom Carlos Alcaraz, big-serving John Isner or two-time Wimbledon champ Andy Murray to reach the final. Nadal faces a bit of an easier road but could have to get past 2021 finalist Mario Berrettini to get there.

Caesars Sportsbook has Djokovic listed as the clear -145 favorite (risk $145 to win $100) in its latest 2022 Wimbledon men's singles odds. Berrettini is priced at +550, ahead of Nadal (+650) and Alcaraz (+800). Hubert Hurkacz and Felix Auger-Aliassime are both at +1400, Murray is 25-1 and Isner is a 50-1 long shot. Before making any men's 2022 Wimbledon picks or predictions, you need to see who tennis expert Sean Calvert is backing.

Calvert is the famed handicapper who called Stan Wawrinka winning the 2014 Australian Open at 60-1 -- the last Australian title won by someone other than Novak Djokovic or Roger Federer. In 2019, Calvert took down a huge score on Dominic Thiem winning Indian Wells at 80-1, among many stunning calls. 

Now, Calvert has scrutinized the latest Wimbledon 2022 odds and released his coveted best bets to win it all. He's sharing all of his expert picks and analysis at SportsLine.

Top 2022 Wimbledon men's predictions

One surprise: Alcaraz won't be a threat in London this fortnight. The youngster's talent is clear, and he has been opening a lot of eyes with his play this season, but the expert is fading him. Alcaraz is 32-4 this season with two ATP 1000 crowns (Miami, Madrid) and two ATP 500 titles (Barcelona, Rio). Two of his losses were to Nadal at Indian Wells and Zverev in the French Open quarterfinals. He has been on an impressive run, without a doubt.

Still, Calvert knows he has very little experience on grass, and an elbow issue kept him from playing in the tune-up events in the run-up to Wimbledon. He has played just two senior matches on grass, and one of those was a quick three-set loss to Medvedev in the first round at Wimbledon last year. He faces another tough opener this year, and Calvert said he won't be shocked if Alcaraz stumbles in his opener against German veteran Jan-Lennard Struff.

How to make 2022 Wimbledon men's picks 

Instead, Calvert is backing two huge underdogs to reach the final who both come in at 40-1 or higher. Both of these players should be able to take advantage of the weakened draw and are capable of pulling off major upsets. See who they are at SportsLine.

So who wins the 2022 Wimbledon men's singles title? And which long shots could make a serious run at the Grand Slam title? Visit SportsLine now to see Sean Calvert's bets for Wimbledon 2022, all from the renowned tennis expert who called Wawrinka winning the Australian Open at 60-1, and find out. 

2022 Wimbledon odds, favorites 

Novak Djokovic -140
Matteo Berrettini +550
Rafael Nadal +650
Carlos Alcaraz +800
Hubert Hurkacz +1400
Felix Auger-Aliassime +1400
Nick Kyrgios +1800
Stefanos Tsitsipas +1800
Marin Cilic +2000
Andy Murray +2500
Denis Shapovalov +3500
Taylor Fritz +5000
John Isner +5000
Jannik Sinner +5000
Cameron Norrie +5000
Casper Ruud +6500
Tim Van Rijthoven +6500