Tennis: Wimbledon

The biggest story of the 2022 U.S. Open continues Friday at 7 p.m. ET as Serena Williams takes on Jla Tomljanovic in the third round at Arthur Ashe Stadium in Flushing Meadows. The 40-year-old Williams has drawn the attention of both the sports and entertainment worlds as she is expected to retire at the conclusion of the tournament. Her hopes for a seventh U.S. Open championship and record-tying 24th Grand Slam title remained alive when she upset World No. 2 and second seed Anett Kontaveit 7-6 (7-4), 2-6, 6-2 in the second round on Wednesday.

Williams is a -160 favorite (risk $160 to win $100) in the latest Williams vs. Tomljanovic odds from Caesars Sportsbook, while Tomljanovic is a +125 underdog. The over/under for total games is set at 21.5, with Williams favored by 2.5 games. Before making any Williams vs. Kovinic picks or 2022 U.S. Open predictions, you need to see what tennis expert Jose Onorato has to say.

Onorato grew up playing competitive tennis in Caracas, Venezuela. After coming to the U.S., he trained with famed coach Nick Bollettieri at IMG Academy in Florida and faced players like Robert Farah, now one of the world's top-ranked doubles players.

Onorato, who holds dual degrees in finance and economics from the University of Miami, does extensive research before placing any tennis bet. He studies current form, players' tendencies on a particular surface, weather conditions and many other relevant factors. That systematic approach helped Onorato go 69-46 - up 54.98 units - from January through July.

Now, Onorato has scrutinized the latest U.S. Open 2022 odds and released his coveted best bet for the Williams vs. Tomljanovic third-round match. He's sharing his pick and analysis only at SportsLine.

Serena Williams vs. Ajla Tomljanovic preview

Williams is hoping her U.S. Open career does not end the way it began in 1998 -- with a third-round loss. She extended her records to 103 wins at Arthur Ashe Stadium and 367 in Grand Slam events with her triumph over Kontaveit on Wednesday. Williams, who never has faced Tomljanovic, has advanced to at least the quarterfinals in 17 of her 20 appearances in the U.S. Open -- including each of the last 12.

Tomljanovic is coming off a 1-6, 6-2, 7-5 victory against Evgeniya Rodina in the second round. The 29-year-old, who was born in Croatia but has permanent residency and citizenship in Australia, has advanced to the third round of the U.S. Open for a second straight year after failing to win at least two matches in her first seven appearances. Tomljanovic's career-best showing in WTA singles tournaments has been the quarterfinals, which she has reached three times - including Wimbledon in July and last month's Western & Southern Open in Cincinnati. See who Onorato is backing right here.

How to make Williams vs. Tomljanovic picks

In addition to his analysis, Onorato has released a best bet for the third-round match. Be sure to see Onorato's pick and analysis before locking in your 2022 U.S. Open picks for Tomljanovic vs. Williams.

Who wins Williams vs. Tomljanovic in the third round of the 2022 U.S. Open? And what pick could lead to a huge return? Visit SportsLine now to see Jose Onorato's best bet for Tomljanovic vs. Williams, all from the tennis expert who knows the game from a player's perspective.