It's only Week 4, but there are a slew of notable injuries as the regular season enters its second quarter. While several high-profile players entered this weekend's games with injuries, several more sustained injuries while trying to lead their teams to victory. 

Several quarterbacks were the subject of notable injuries over the weekend. More than one marquee running back also sustained a significant injury. Monday also brought an update on the status of Tua Tagovailoa, whose recent injuries have led to immediate changes regarding the league's handling of concussions

Here's a rundown of several notable injuries entering Monday night's game between the Rams and 49ers.

Tua Tagovailoa 

Tua Tagovailoa
MIA • QB • #1
CMP%69.6
YDs1035
TD8
INT3
YD/Att9
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Dolphins head coach Mike McDaniel announced Monday that Tagovailoa will not play in Miami's upcoming game against the Jets. Tagovailoa remains in the concussion protocol after he was briefly hospitalized following a hit during Miami's loss in Cincinnati last Thursday night. Veteran Teddy Bridgewater will start in place of Tagovailoa, who does not currently have a timetable for his return to the field. (Read more)

Cordarrelle Patterson 

Cordarrelle Patterson
ATL • RB • #84
Att58
Yds340
TD3
FL0
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Patterson is being placed on injured reserve following a knee procedure that took place following Atlanta's Week 4 win over the Browns. Patterson missed practice time last week while dealing with the injury. The four-time All-Pro will miss at least the Falcons' next four games. (Read more)

Javonte Williams 

Javonte Williams
DEN • RB • #33
Att47
Yds204
TD0
FL1
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Denver's second-year running back will miss the remainder of the season after sustaining a torn ACL during the Broncos' Week 4 loss to the Raiders. With Williams out, former Pro Bowl running back Melvin Gordon will likely receive a heavier workload moving forward. (Read more)

Jonathan Taylor 

Jonathan Taylor
IND • RB • #28
Att81
Yds328
TD1
FL1
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Taylor has a chance to face the Broncos on Thursday night after tests on his ankle came back negative, according to ESPN. The reigning NFL rushing champion sustained the injury during Sunday's loss to the Titans. (Read more)

Daniel Jones 

Daniel Jones
NYG • QB • #8
CMP%63.8
YDs631
TD3
INT2
YD/Att6.01
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The Giants' starting quarterback is considered day-to-day after sustaining an ankle injury during Sunday's win over the Bears, according to NFL Media. Giants coach Brian Daboll said Monday that Jones was "feeling a little bit better today. We'll just see how it goes." Daboll added that the Giants will likely work out a few quarterbacks after Tyrod Taylor sustained a concussion during Sunday's game. 

Davis Webb, who is currently on the practice squad, would be in line to start if Jones and Taylor are unable to play in the Giants' following game in London against the Packers

Treylon Burks 

Treylon Burks
TEN • WR • #16
TAR16
REC10
REC YDs129
REC TD0
FL0
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Burks sustained a turf toe injury during Sunday's win over the Colts, according to NFL Media. While it will take time to recover from, the injury does not require surgery. 

Jamison Crowder 

Jamison Crowder
BUF • WR • #80
TAR13
REC6
REC YDs60
REC TD0
FL0
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Buffalo's wideout will likely go on injured reserve after breaking his ankle during Sunday's win over the Ravens, head coach Sean McDermott told reporters Monday (via NFL Media). Crowder will undergo additional tests to find out the overall significance of his injury. (Read more)

Shaquille Leonard 

Leonard has been ruled out of the Colts' upcoming Thursday night game against the Broncos with a concussion. The five-time Pro Bowl linebacker made his season debut Sunday after recovering from back surgery that took place in June. 

Jahan Dotson 

Jahan Dotson
WAS • WR • #1
TAR22
REC12
REC YDs152
REC TD4
FL0
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The rookie receiver's hamstring injury could keep him out for 1-2 weeks, Commanders coach Ron Rivera said Monday. Dotson has four touchdowns in as many games, which includes one score during Sunday's loss in Dallas. 

Lewis Cine 

Minnesota's first-round pick is in "good spirits" despite suffering a compound fracture to his lower leg during Sunday's win over New Orleans, according to NFL Media. The injury will sideline him for the remainder of the season. 

Cine will remain in London until he is ready to return to Minnesota. 

Randy Gregory 

Gregory is expected to miss anywhere from 2-6 weeks as he is set to undergo surgery on his knee, according to NFL Media. The veteran pass rusher sustained the injury during Sunday's win over the Raiders. Gregory has made a quick impact in Denver, as the Broncos are currently fifth in the NFL in scoring defense and first in red zone defense.