Todd Gurley headlined the injury report on Friday. He'll do so again on Saturday.
The Rams' All-Pro running back was initially announced as doubtful for Los Angeles' home game against San Francisco by head coach Sean McVay. Gurley, who has been dealing with a quadriceps injury, was inactive during the Rams' first two practices in preparation for Sunday's game. On Saturday, the Rams confirmed he will not play and signed running back John Kelly to the active roster.
Malcom Brown, who is second to Gurley in rushing yards and rushing touchdowns, should get the start for Sunday's game. Brown, who had just one carry in last week's loss to Seattle, scored two touchdowns in L.A.'s season-opening victory against the Carolina Panthers.
Other big names to keep an eye on from an injury standpoint include Panthers running back Christian McCaffrey, Saints running back Alvin Kamara, Steelers quarterback Mason Rudolph, Jaguars cornerback Jalen Ramsey, Ravens receiver Marquise Brown and Chiefs receiver Tyreek Hill, among others.
There isn't a single team that isn't dealing with at least one significant injury this week, as the NFL season is nearing the midway point. Several teams will look to get healthy during their upcoming bye weeks.
For the latest updates and analysis of the injuries heading into Week 6, check out our rundown below.
Panthers (-2.5) vs. Buccaneers in London
- Panthers: DB Natrell Jamerson (foot), T Greg Little (concussion), LB/DE Christian Miller (ankle), QB Cam Newton (foot), G Trai Turner (ankle) OUT; S Eric Reid (ankle), LB Shaq Thompson (ankle), CB Donte Jackson (groin), TE Chris Manhertz (concussion), T Dennis Daley (groin) QUESTIONABLE
- Buccaneers: G Alex Cappa (forearm), ILB Jack Cichy (elbow), T Demar Dotson (hamstring), WR Breshad Perriman (hamstring), guard Zack Bailey (foot, ankle) OUT; RB T.J. Logan (ankle) QUESTIONABLE
One player that will be on the field for the Panthers Sunday is running back Christian McCaffrey, who was included on Carolina's injury report throughout the week with a back injury. McCaffrey was a full participant on Thursday and Friday after being held out of Wednesday's practice. Logan was a limited participant during the Bucs' last two practices after being held out of Wednesday's practice.
Bengals at Ravens (-11)
- Bengals: DT Ryan Glasgow (thigh), WR A.J. Green (ankle), OT Andre Smith (ankle), OT Cordy Glenn (concussion), DE Kerry Wynn (concussion), DE Carlos Dunlap (knee) OUT; S Shawn Williams (thigh) QUESTIONABLE
- Ravens: CB Jimmy Smith (knee) OUT; WR Marquise Brown (ankle), ILB Patrick Onwuasor (ankle), TE Mark Andrews (shoulder) QUESTIONABLE
While Andrews was a full participant during Friday's practice, Brown and Onwuasor did not practice throughout the week. Brown, the team's first-round pick and leading receiver, sustained his injury during the second of Baltimore's Week 5 win over Pittsburgh. Ravens coach John Harbaugh said that Brown will be a game-time decision against Cincinnati. Williams, one of the Bengals' top defensive players, was limited on Friday after being held out of the team's first two practices.
Seahawks (-1.5) at Browns
- Seahawks: C/G Ethan Pocic (mid back) OUT; T Duane Brown (biceps), G/T D.J. Fluker (hamstring) DOUBTUL; RB Rashaad Penny (hamstring) QUESTIONABLE
- Browns: T Kendall Lamm (knee), CB Denzel Ward (hamstring), CB Greedy Williams hamstring) QUESTIONABLE
While Brown and Fluker did not practice throughout the week, Penny, who has complemented Chris Carson in the backfield this season when healthy, was a full participant on Thursday and Friday after sitting out Wednesday's practice. Lamb, Ward and Williams were each limited during the Browns' first two practices in preparation for Sunday's game. Reserves T.J. Carrie and Terrance Mitchell would start at cornerback if Ward and Williams' can't go. A sixth year veteran, Carrie has 47 career starts under hit belt, while Mitchell, also a six year veteran, has 21 career starts to his credit.
Texans at Chiefs (-4.5)
- Texans: C/G Greg Mancz (concussion) OUT; RB Taiwan Jones (hip), WR Kenny Stills (hamstring), CB Jonathan Joseph (wrist/hip) QUESTIONABLE
- Chiefs: T Eric Fisher (groin), DT Chris Jones (groin), LB Dorian O'Daniel (hamstring) OUT; WR Sammy Watkins (hamstring), G Andrew Wylie (ankle) DOUBTFUL; WR Tyreek Hill (shoulder), LB Anthony Hitchens (groin) QUESTIONABLE
Hill, who hasn't played since Week 1, was a limited participant throughout this week's practices for the Chiefs. The Chiefs are reportedly optimistic that Hill will be on the field for Sunday's game. Jones and Still were limited throughout the week for Houston, while Joseph was limited during Friday's practice after not being a full participant on Wednesday and Thursday.
Saints at Jaguars (-1.5)
- Saints: QB Drew Brees (right thumb), WR Tre'Quan Smith (ankle), DE Trey Hendrickson (neck) OUT; RB Alvin Kamara (ankle) QUESTIONABLE
- Jaguars: TE Josh Oliver (hamstring) OUT; CB Jalen Ramsey (back), DE Lerentee McCray (oblique) QUESTIONABLE
Kamara, who had 104 all-purpose yards in New Orleans' Week 5 win over Tampa Bay, did not practice on Friday after being limited on Thursday. Latavius Murray, a seven-year veteran, will likely start at running back if Kamara can't go. Murray, a former Oakland Raider and Minnesota Viking, has 94 rushing yards and a touchdown on 24 carries this season. Ramsey, one of the NFL's top cornerbacks, is in jeopardy of missing his third consecutive game due to injury. He was limited throughout the week in preparation for the Jaguars' home game against the Saints.
Eagles at Vikings (-3)
- Eagles: RB Corey Clement (shoulder), CB Ronald Darby (hamstring), WR DeSean Jackson (abdomen), DT Tim Jernigan (foot), CB Avonte Maddox (concussion, neck), RB Darren Sproles (quadricep) OUT
- Vikings: LB Ben Gedeon (concussion), G Josh Kline (foot) OUT; LB Kentrell Brothers (hamstring/wrist) QUESTIONABLE
While Philadelphia will be without several players on Sunday, they will have receiver Nelson Agholor, who was a limited participant Friday after sustaining an illness. Defensive backs Orlando Scandrick (illness), Rodney McLeod (knee) and Sidney Jones (hamstring) will play despite being on the Eagles' injury report throughout the course of the week. Brothers was a limited participant throughout the Vikings' practices this week.
Redskins (-3.5) at Dolphins
- Redskins: LB Josh Harvey-Clemons (hamstring), G Wes Martin (chest), TE Jordan Reed (concussion), TE Vernon Davis (concussion), S Deshazor Everett (ankle) OUT; OT Donald Penn (hamstring) QUESTIONABLE
- Dolphins: CB Johnson Bademosi (ankle), RB Kalen Ballage (foot), OT Jesse Davis (elbow), WR Jakeem Grant (hamstring), LB Trent Harris (foot), CB Xavien Howard (knee), S Reshad Jones (ankle), CB Chris Lammons (toe), S Bobby McCain (hamstring, shoulder), WR Albert Wilson (calf/hip) QUESTIONABLE
Every player that got a tag on the Dolphins' injury report this week has been ruled as questionable for Sunday's game against the also-winless Redskins. Top corner Howard has been limited in practice all week, while Bademosi and Ballage didn't appear on the team's injury report until Friday. Penn was a full participant for the Redskins on Friday after missing Wednesday's practice and being limited on Thursday.
49ers at Rams (-3)
- 49ers: FB Kyle Juszczyk (knee), T Mike McGlinchey (knee), CB Ahkello Witherspoon (foot) OUT; TE George Kittle (groin) QUESTIONABLE
- Rams: RB Todd Gurley (quad), OLB Clay Matthews (jaw), CB Aqib Talib (ribs) OUT
Kittle, who caught six passes for 70 yards an a score in San Fran's 31-3 win over Cleveland on Monday night, did not appear on the team's injury report on Wednesday and Thursday before being a limited participant during Friday's practice. Ross Dwelley, a two-year veteran with four career catches to his name, would start for the 49ers if Kittle can't go against the Rams. Troy Hill will replace Talib at CB for Sunday's AFC West matchup with San Francisco. Hill, a five-year veteran, has appeared in five games this season but has yet to receive a start. Gurley being ruled out impacts the Rams gameplan in a major way.
Falcons (-2.5) at Cardinals
- Falcons: P Matt Wile (quad), CB Desmond Trufant (toe), CB Blidi Wreh-Wilson (groin) OUT;
- Cardinals: ILB Dennis Gardeck (ankle), ILB Ezekiel Turner (hamstring), S Charles Washington (shoulder) OUT; RB David Johnson (back), ILB Haason Reddick (shoulder), OLB Terrell Suggs (back), WR Damiere Byrd (hamstring), WR Christian Kirk (ankle), P Andy Lee (right hip), DE Zach Allen (neck), CB Trevor Williams (hip) QUESTIONABLE
Johnson, the Cardinals' former All-Pro running back, is questionable after being limited on Friday and not practicing on Wednesday and Thursday. While the Falcons will be down a pair of cornerbacks for Sunday's game, Pro Bowl receiver Julio Jones will play on Sunday despite missing significant practice time with a hip injury. Cornerbacks Damontae Kazee, Kendall Sheffield and Jordan Miller will get more reps on Sunday with Trufant and Wreh-Wilson out for the Falcons.
Cowboys (-7) at Jets
- Cowboys: WR Randall Cobb (hip/back), T La'el Collins (knee), T Tyron Smith (ankle) QUESTIONABLE
- Jets: DL Henry Anderson (shoulder), RB Trenton Cannon (foot/ankle), LB C.J. Mosley (groin), G Kelechi Osemele (shoulder/knee/illness) DOUBTFUL; CB Nate Hairston (knee), WR Josh Bellamy (shoulder), LB Jordan Jenkins (calf), WR Demaryius Thomas (hamstring/knee) QUESTIONABLE
Collins and Smith did not practice throughout the week, while Cobb missed Thursday and Friday's practices. Cameron Fleming will replace Smith if he can't go on Sunday. Devin Smith and Tavon Austin will look to pick up the slack if Cobb can't go against the Jets. Mosley's injury kept him out throughout the week for the Jets, while Thomas, Jenkins and Bellamy were limited throughout the week.
Titans at Broncos (-2)
- Titans: OLB Sharif Finch (shoulder), DE Cameron Wake (hamstring) OUT; CB Chris Milton (calf), RB Rod Smith (groin) QUESTIONABLE
- Broncos: CB Bryce Callahan (foot) OUT; T Ja'Wuan James (knee), S Trey Marshall (lower leg), DB Duke Dawson Jr. (foot) QUESTIONABLE
Milton did not practice in the week leading up to Sunday's game against Denver, while Smith was a full participant Friday after not appearing on the team's injury report earlier in the week. Guard Kevin Pamphile and tight end Delanie Walker are good to go for Tennessee. Marshall was limited throughout the week for the Broncos, while Dawson missed Wednesday's practice before being limited on Thursday and Friday.
Steelers at Chargers (-6.5)
- Steelers: QB Mason Rudolph (concussion), RB Jaylen Samuels (knee), WR James Washington (shoulder), LB Mark Barron (hamstring), CB Steven Nelson (groin) OUT
- Chargers: S Nasir Adderley (hamstring), K Michael Badgley (right groin), RB Justin Jackson (calf) DOUBTFUL; DE Melvin Ingram III (hamstring), TE Hunter Henry (knee) QUESTIONABLE
Pittsburgh rookie quarterback Devlin Hodges will make his first career start in relief of Rudolph. Donte Moncrief, who signed a two-year deal with the Steelers this offseason, will likely see significant playing time Sunday with Washington out. Nelson, initially listed as questionable, has been downgraded to out this week. Vince Williams will replace Barron in the starting lineup, while 2016 first round pick Artie Burns will start for Nelson. Henry was a full participant on Friday after being limited on Wednesday and Thursday, while Ingram was limited on Friday after not practicing the previous two days.
Lions at Packers (-4)
- Lions: DT Mike Daniels (foot), CB Amani Oruwariye (knee) OUT; WR Danny Amendola (chest), DB Quandre Diggs (hamstring), DL Da'Shawn Hand (elbow), TE T.J. Hockenson (concussion), DT A'Shawn Robinson (knee), CB Darius Slay (hamstring) QUESTIONABLE
- Packers: WR Davante Adams (toe), S Darnell Savage, TE Robert Tonyan OUT; CB Tony Brown (hamstring) DOUBTFUL
Another week, another absence for Adams as he battles turf toe that will sideline him for his second consecutive game. Savage will be the key starter sidelined for the Packers defense, keeping two top weapons off the field. Daniels being out threatens the Lions' defensive line depth, and the concerns linger with both Hand and Robinson being questionable. The biggest defensive question mark is Slay, because he's the best corner on the team, but was limited in practice all week. Amendola was limited all week as well, joining a list of concerning ailments leading into an all-important early NFC North clash.