Chen (1-3) surrendered an RBI double in the second inning to open the scoring, then served up a two-run homer to Justin Ruggiano in the fourth. He lost the quality start in the seventh, when he allowed an RBI triple.
"He was good," manager Buck Showalter said, per MASNSports.com. "Left a couple breaking balls up that he paid for, but other than that he was crisp. Deep into the game and wasn't much margin for error for him the way their guy was pitching. I thought he pitched pretty well all things considered. Just a couple of mistakes he paid for. A breaking ball he left that he was trying to get it obviously in a different spot and left it over the plate.
"Wei-Yin gave us seven pretty solid innings and we'll take that. Felt like we would make a run at him at some point if we could stay in touch with him. We had some good opportunities, but obviously against a quality back of the game pitcher."
Chen had delivered four straight quality starts coming into Wednesday. He owns a 2.90 ERA and 38:14 K:BB ratio in 49 2/3 innings. The lefty is scheduled to face the Astros Monday.
Tillman missed his last start with an illness and is now dealing with the back issue. It is unclear when Tillman's next start would come. He is 2-5 with a 6.34 ERA in 38 1/3 innings of work so far this season.
"I thought he had a good breaking ball tonight," manager Buck Showalter said, per MLB.com. "Slider had some late life and bite to it. Commanded the inner half of the plate, which you're going to have to do with that many quality right-handed hitters in the lineup."
Chen was touched for a first-inning solo homer from Albert Pujols.
"Overall, I felt pretty good," Chen said. ''Well, there was those bumpy innings in the first two, but luckily I made adjustments."
Chen has now allowed three earned runs or less in all seven of his starts this season.
"That was a tough lineup for a left-handed pitcher," Orioles manager Buck Showalter. "Wei-Yin was really good."
Chen returns to the mound for his next start Thursday against the Mariners.
Chen (1-1) was staked to a 4-0 lead on a trio of home runs by the end of the fourth inning, and he enjoyed a 5-0 lead by the team he allowed his only run of the game on a sacrifice fly in the bottom of the fifth. While he has yet to allow more than three earned runs in a start, Saturday's win was his first in six tries.
"He's had a couple [good starts] like this," manager Buck Showalter said of Chen. "He was carrying a so-so changeup, a so-so slider, but he had command of the fastball, which really gave him four pitches in all the quadrants."
Chen owns a 2.52 ERA and 27:12 K:BB ratio in 35 2/3 innings. He's slated to face the Angels at home Friday.
Chen has delivered quality starts in two straight outings and three of his last four starts, but he's still looking for his first win of the season.
"My last outing, I felt pretty great," Chen said through his interpreter. "All I wanted to do was keep the same feeling and not do anything extra and that's what I did today."
He surrendered a solo home run in the second inning, and the Rays were able to plate one more on a fifth-inning single.
Chen owns a 2.83 ERA and 20:11 K:BB ratio in 28 2/3 innings. His next chance to earn his first win comes Saturday against the Yankees in New York.
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