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The top two teams in the National League collide for the second straight night when the Los Angeles Dodgers and New York Mets play the middle contest of a three-game set. The Dodgers (90-38) won the first game of the series on Tuesday, 4-3, and have emerged as the favorites to win the World Series. Meanwhile, the Mets (82-48) are trying to hold off the Braves in the NL East. New York is a -165 favorite in the latest Mets vs. Dodgers odds from Caesars Sportsbook, while Los Angeles is a +140 underdog.

First pitch is set for 7:10 p.m. ET at Citi Field in Queens, N.Y. The game is one of 15 on the MLB schedule for Wednesday. Elsewhere in the majors, the Braves' Kyle Wright looks to become the first 17-game winner in the majors, against the Rockies, and the Minnesota Twins will try to extend their winning streak to six when they host the Boston Red Sox. Before making any MLB picks or parlays, be sure to see the predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times, and it is a 309-266 on top-rated MLB money-line picks since the start of the 2021 season. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win the World Series. Anybody who has followed the model has seen profitable returns.

Now, the model has locked in three confident MLB best bets for Wednesday. They all involve games at 7:10 p.m. ET or later, so there's still time to get these MLB picks in. If you successfully parlay the picks, you'd be looking at a payout of 26-1. You can only see the model's MLB picks at SportsLine. 

Top MLB picks today

After simulating every game on Wednesday 10,000 times, the model is high on the NL West-leading Dodgers (+140) to knock off the Mets. Los Angeles has had Jacob deGrom's number throughout his career as in 10 starts against the Dodgers, the Mets ace is 0-4. In addition, Los Angeles is 19-5 this season when lefty Tyler Anderson takes the mound.

The Dodgers also have dominated the Mets at Citi Field recently. In its last 15 games in Queens, a stretch that dates back to May 2016, Los Angeles is 14-1. The Dodgers also are 10-3 against the Mets in the last 13 games between the teams played anywhere. See who else to back right here.

How to make MLB picks and parlays for Wednesday

The model also locked in three other best bets for Wednesday, including a play on another big underdog. You can see the model's MLB Wednesday best bets and parlay only at SportsLine.

What MLB picks should you target for a payout of 26-1? And what underdog does the model like on Wednesday? Visit SportsLine now to see the MLB best bets from an advanced model that is on a 309-266 run on top-rated MLB money-line picks since the start of 2021.