STANFORD, Calif. -- Chasson Randle scored 17 points, Josh Huestis had 14 points and 13 rebounds, and Stanford stunned Oregon on the big stage again by routing the 10th-ranked Ducks 76-52 Wednesday night.

More than two months after Stanford's football team handed Oregon its only loss of the season, the Cardinal (13-8, 4-4 Pac-12) dominated the Ducks from the start for the program's first victory over a top 10 team in almost five years.

Carlos Emory scored 12 points and Arsalan Kazemi had six points and nine rebounds in the first conference loss of the season for the Ducks (18-3, 7-1), whose nine-game winning streak also ended. Oregon had matched its highest ranking since March 2007 this week but surely will take a tumble in the AP poll now.

Dwight Powell added 12 points and 13 rebounds, and Aaron Bright finished with 12 points as Stanford built a 25-point lead early in the second half and coasted to the buzzer. Stanford outshot Oregon 52 to 35 percent from the floor. The Cardinal also went 8 of 14 from 3-point range, while the Ducks converted only 4 of 16 from beyond the arc.

Oregon's best start in conference play since finishing 10-0 in the 1925-26 season is over. Once again, the Ducks can thank Stanford for ruining an undefeated run.

The Cardinal football team also outlasted Oregon in November on the way to a Pac-12 title and Rose Bowl victory. Coincidentally, Jordan Williamson, who kicked the winning 37-yard field goal in overtime at top-ranked Oregon, and a few teammates stood in the first row of the Stanford student section.

The Cardinal men's basketball team hadn't beaten a ranked opponent since Jan. 13, 2011, when it topped Washington 58-56 at home. The last top 10 team Stanford had upset came when the Cardinal won at Washington State 67-65 in overtime on Feb. 2, 2008.

Despite Oregon's strong start, the Ducks entered the game as 2 1/2-point underdogs. In the end the only surprise was that Las Vegas bookmakers didn't make the line even higher.

Stanford followed up its 87-57 win at Utah on Sunday - its most lopsided league victory in nine years - with another runaway performance.

The only celebration Oregon enjoyed came after Kazemi's two-handed slam in the opening moments. That faded fast when the Oregon forward fell hard going for a rebound on the next defensive possession.

Kazemi, who had concussion in a win against Nevada on Dec. 31, lay on the court holding his head for more than a minute before being helped up by a team trainer. He later returned and showed no effects from the injury.

With Kazemi recovering on the bench, Stanford started its surge.

Randle, Powell, Bright and John Gage each hit a 3-pointer during an 18-2 run that brought the sparse crowd roaring to its feet. The Cardinal clamped down on defense, too, pushed the pace for quick scores to go ahead 20-8 in the first 8 minutes.

Oregon missed its first six shots from beyond the arc and committed 20 turnovers, including three egregious errors just before the break. Stanford scored after each one, part of a quick 6-0 burst capped by Anthony Brown's bank hook that helped the Cardinal carry a 35-22 lead into the locker room.

Stanford started even faster in the second half.

After E.J. Singler's 3-pointer cut the Cardinal's lead to 10, the Ducks never got closer. Powell started a three-point play with a layup over Singler, then made a runner and another from beyond the arc as the Cardinal gained control for good.

Huestis cleaned up a miss with a putback dunk, and Bright made a jumper and a 3-pointer to put the Cardinal ahead 54-29 with 12:08 remaining to put the game out of reach.

Stanford students taunted Oregon in the final minutes with chants of "overrated."