Wolfe will remain with the team through training camp and the preseason, but will no be eligible to return after that until the team's Week 4 matchup against the Vikings.
Wolfe said that a medication he took triggered the positive test.
"During the offseason I took a medication which is on the banned substance list," he said in the statement. "The medication is not a substance which would enhance my on-field performance in any way and I genuinely was unaware that it was prohibited, but players are responsible for what is in their bodies.
"I will certainly exercise far greater caution in the future and will seek advice relating to the permissibility of any and all medications."
Wolfe recorded 35 tackles and 1.5 sacks in 16 games for the Broncos last season.
Manning came into the contest listed as probable due to a thigh injury. He was never really expected to miss the contest. Sanders was listed as questionable with a hip issue. He was a limited participant in practice all week.
The team will also have nearly all of their probable players. That means
Those included running back
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