Alan Major publicly announced his leave on Tuesday. His return is not known. (USATSI)

The University of Charlotte announced Tuesday afternoon that, for the second time in less than a year, its coach, Alan Major, will indefiintely leave the team due to health concerns.

In a statement, the school writes, "Major, who took a similar medical leave during the summer, approached Director of Athletics Judy Rose to request the leave due to a return of health conditions."

The 49ers, 6-7 and with an upcoming road game Thursday against Western Kentucky, have been coached by Major since 2010.

"This is an extremely difficult basketball decision for me to make, but more importantly, it’s a life and health decision," Major said in a statement, which did not disclose the threatening condition(s) he's facing. "It will be difficult being away from the team but I’ll maintain contact with the guys on a regular basis. I have the best staff in the country and those guys are fully-prepared to take our team into battle. I look forward to attacking this recovery process and getting back to leading this program into the future."

The team will be run by associate head coach Ryan Odom, who took over program duties during Major's hiatus in the spring and summer of 2014.

"There is no timetable for Major’s return, at this point," Charlotte's press releases states. "Out of respect for Major’s privacy, no further details will be released."