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The Memphis Tigers will take on the Arkansas State Red Wolves at 7 p.m. ET on Saturday at Centennial Bank Stadium. Memphis won its first game of the 2021 season over Nicholls State, 42-17. The Tigers went 8-3 last year and won the Montgomery Bowl. Meanwhile, the Red Wolves beat Central Arkansas 40-21 in their opener after finishing 4-7 last year.

The Tigers are favored by 5.5-points in the latest Arkansas State vs. Memphis odds from Caesars Sportsbook, and the over-under is set at 64.5. Before entering any Memphis vs. Arkansas State picks, you'll want to see the college football predictions from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of over $3,500 for $100 players on its top-rated college football picks against the spread. It also enters Week 2 of the 2021 season on a 63-45 run on all top-rated college football picks. Anyone who has followed it has seen HUGE returns.

Now, the model has set its sights on Arkansas State vs. Memphis. You can head to SportsLine to see its picks. Here are several college football odds for Arkansas State vs. Memphis:

  • Arkansas State vs. Memphis spread: Arkansas State +5.5
  • Arkansas State vs. Memphis over-under: 64.5 points

What you need to know about Arkansas State

In the opening week win, quarterback Layne Hatcher threw four touchdown passes. He completed all 12 of his attempts and finished with 150 yards. Corey Rucker was named the Sun Belt Conference Offensive Player of the Week after catching nine passes for 138 yards and three touchdowns in the opener. The Red Wolves scored 34 of the game's final 48 points. 

The Red Wolves finished with 519 yards on offense last week. The last time Arkansas State started 2-0 was 2008. The Red Wolves have won four of the last seven meetings with the Tigers but have lost two straight in the series. 

What you need to know about Memphis

The Tigers won their eighth consecutive home opener and 16th straight home game last week. Brandon Thomas rushed for 147 yards and a TD on 16 attempts. Marquavius Weaver and Rodrigues Clark also had rushing TDs. Quarterback Seth Henigan threw for 265 yards and a TD. 

Memphis beat Arkansas State in the season opener last year, 37-24. Clark had 105 rushing yards and a TD in that matchup. The Tigers lead the all-time series against the Red Wolves, 30-24-5. 

How to make Arkansas State vs. Memphis picks

The model has simulated Arkansas State vs. Memphis 10,000 times and the results are in. We can tell you that the model is leaning over, and it's also generated a point-spread pick that is hitting in 60 percent of simulations. You can only see the pick at SportsLine.

So who wins Arkansas State vs. Memphis? And which side of the spread hits 60 percent of the time? Visit SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks.