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The Brooklyn Nets visit the Philadelphia 76ers in an Atlantic Division clash on Wednesday evening. Brooklyn enters with a rest disadvantage after traveling in from Minnesota following an afternoon game on Tuesday. Philadelphia last played on Monday in Dallas, trampling the Mavericks by a 119-95 margin. The Sixers are 37-17 overall and 20-5 at Wells Fargo Center this season. The Nets will be without Kevin Durant, James Harden, Blake Griffin and LaMarcus Aldridge on Wednesday against Philadelphia.

Tip-off is at 7 p.m. ET in Philadelphia. William Hill Sportsbook lists the 76ers as 8.5-point home favorites, while the over-under, or total number of points Vegas thinks will be scored, is 225.5 in the latest Sixers vs. Nets odds. Before you make any Nets vs. Sixers picks, be sure to see the NBA predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every NBA game 10,000 times, and it has returned over $9,100 in profit on its top-rated NBA picks over the past two-plus seasons. The model is up over $1,100 on its top-rated picks this season, and dating back to last year, it entered Week 17 of the 2020-21 NBA schedule on a stunning 95-59 roll on top-rated NBA picks against the spread. Anybody who has followed it has seen huge returns.

Now, the model has set its sights on Nets vs. 76ers. You can head to SportsLine to see its picks. Now, here are several NBA odds and betting trends for 76ers vs. Nets:

  • Nets vs. Sixers spread: 76ers -8.5
  • Nets vs. Sixers over-under: 225.5 points
  • Nets vs. Sixers money line: Philadelphia -350, Brooklyn +290
  • BKN: The Nets are 3-7 against the spread in the last 10 games
  • PHI: The 76ers are 5-5 against the spread in the last 10 games

Why the Nets can cover

Brooklyn has an elite offense by any description, and the Nets are scoring 1.17 points per possession despite injury issues throughout the 2020-21 campaign. The Nets led the league in both effective field goal percentage and true shooting percentage (more than 60 percent), illustrating their overall shooting efficiency, and they have the NBA's best mark on two-point shots. Brooklyn takes care of the ball at a high level, ranks in the top eight in assists, and posts an assist-to-turnover ratio of nearly 2-to-1. The Nets also work well on the margins, generating a top-10 mark in free throw creation rate. 

Defensively, Brooklyn isn't nearly as strong, but the Nets do rank in the top 10 in both free throw prevention and blocked shots. The Nets contest well on the perimeter, leading to an above-average effective field goal percentage allowed, and Philadelphia has a notable weakness. The 76ers fail to take care of the ball, turning the ball over on 14.7 percent of possessions, which ranks near the bottom of the NBA.

Why the 76ers can cover 

Philadelphia is led by one of the best players in the NBA in Joel Embiid. The Sixers are 28-8 in games when Embiid plays, and he is averaging 29.6 points and 11.0 rebounds per contest. Beyond that, Philadelphia out-scores opponents by 13 points per 100 possessions this season with Embiid on the court, and he is also flanked by top-tier players in Tobias Harris and Ben Simmons. 

The 76ers are an elite defensive team, entering Wednesday with the No. 2 mark in the NBA in points allowed per possession (1.06), and they have a path to offensive success against Brooklyn. The Nets are a bottom-tier defensive team with no answers for Embiid, and Brooklyn also struggles to produce turnovers. Finally, Philadelphia projects to have the rebounding edge on both sides of the floor, giving the Sixers an advantage in the possession battle.

How to make Sixers vs. Nets picks

SportsLine's model is leaning over on the total, projecting the teams to combine for 232 points. The model also says one side of the spread hits in over 50 percent of simulations. You can get that pick at SportsLine.

So who wins Nets vs. Sixers? And which side of the spread hits over 50 percent of the time? Visit SportsLine now to find out which side of the spread you need to jump on, all from the model that is on a 95-59 roll on NBA picks.