NFL Week 4 betting, fantasy updates: Odds, line moves, injuries, inactives, lineup advice and more

We're keeping you locked into the betting and fantasy angles leading up to Sunday kickoff for Week 4

The fourth Sunday of the NFL season is about to get underway, and there's plenty of reasons to be excited heading into this slate. The action is kicking off earlier on Sunday as the Vikings and Saints go at it in London. Lamar Jackson and the Ravens are home dogs against Josh Allen and the Bills, who are coming off a humbling loss to the Dolphins. Doug Pederson returns to Philadelphia with his surprising Jaguars, who take on the last unbeaten team in the league. And Tom Brady goes toe to toe against Patrick Mahomes after falling to Aaron Rodgers in Week 3.

We're here to track all the betting and fantasy angles you need to know as we rocket toward kickoff in Week 4, including line movements, injury updates, inactive lists, depth chart news, the buzz on the betting market, key information from our partners at Caesars Sportsbook and plenty more.

Here's a look at the odds (as of Sunday) for the Week 4 slate:

Minnesota Vikings (-3) vs. New Orleans Saints in London, O/U 41.5
Cleveland Browns (-1) at Atlanta Falcons, O/U 47
Buffalo Bills (-3) at Baltimore Ravens, O/U 51
Washington Commanders at Dallas Cowboys (-3), O/U 41.5
Seattle Seahawks at Detroit Lions (-3.5), O/U 48
L.A. Chargers (-5.5) at Houston Texans, O/U 45
Tennessee Titans at Indianapolis Colts (-3.5), O/U 43
Chicago Bears at N.Y. Giants (-3), O/U 39.5
Jacksonville Jaguars at Philadelphia Eagles (-6.5), O/U 45.5
N.Y. Jets at Pittsburgh Steelers (-3.5), O/U 41.5
Arizona Cardinals at Carolina Panthers (-1), O/U 43.5
New England Patriots at Green Bay Packers (-9.5), O/U 40.5
Denver Broncos at Las Vegas Raiders (-2.5), O/U 45
Kansas City Chiefs at Tampa Bay Buccaneers (PICK), O/U 45.5
Monday
Los Angeles Rams at San Francisco 49ers (-1.5), O/U 42.5

Get the latest odds from Caesars Sportsbook and others for each Week 4 game, here.  

[Oct 2, 2022 at 12:24 pm ET · Tyler Sullivan]

The most popular Under bet by tickets is Bears-Giants, per Caesars Sportsbook. It's also the lowest total on the board at 39.5. 

[Oct 2, 2022 at 12:13 pm ET · Tyler Sullivan]

Meanwhile in London: 

[Oct 2, 2022 at 11:39 am ET · Tyler Sullivan]

Cowboys WR Michael Gallup will make his season debut today as well after suffering an ACL tear last season. TE Dalton Schultz is also active. 

[Oct 2, 2022 at 11:37 am ET · Tyler Sullivan]

Welcome back, Shaquille Leonard. Star linebacker makes his 2022 season debut today. 

[Oct 2, 2022 at 11:36 am ET · Tyler Sullivan]

Some heavy-hitters for the Lions and fantasy managers inactive today ... 

[Oct 2, 2022 at 11:35 am ET · Tyler Sullivan]

Jaguars WR Zay Jones (ankle) is officially inactive. 

[Oct 2, 2022 at 11:34 am ET · Tyler Sullivan]

Cordarrelle Patterson is active for Atlanta. 

[Oct 2, 2022 at 11:34 am ET · Tyler Sullivan]

No Keenan Allen for Los Angeles 

[Oct 2, 2022 at 11:33 am ET · Tyler Sullivan]

Ed Oliver sidelined again for Buffalo. Bill do get back Jordan Poyer, Gabe Davis and Mitch Morse. 

[Oct 2, 2022 at 11:32 am ET · Tyler Sullivan]

No Ronnie Stanley for Baltimore today

[Oct 2, 2022 at 11:28 am ET · Tyler Sullivan]

Big bet in DAL-WSH: A New Jersey bettor is all in on the Commanders today, via Caesars Sportsbook. 

$100,000 Commanders +3 (+100)
$100,000 Commanders ML (+143) 

Would win a combined $243,000

[Oct 2, 2022 at 10:57 am ET · Tyler Sullivan]

Some notable total splits from Caesars Sportsbook:

67% of tickets on the total and 81% of the dollars wagered on the total are Under 45.5 for Broncos-Raiders.
64% of tickets on the total and 76% of the dollars wagered on the total are Over 45.5 in Jaguars-Eagles.
54% of tickets on the total and 92% of the dollars wagered on the total are Under 42.5 in Rams-49ers.

64% of tickets on the total are Over 47.5 for Browns-Falcons, but 54% of the dollars wagered on the total are Under 47.5.
76% of tickets on the total are Under 39 for Bears-Giants, but 50% of the dollars wagered on the total are Over 39.

[Oct 2, 2022 at 10:51 am ET · Tyler Sullivan]

Some notable spread splits from Caesars Sportsbook: 

75% of tickets on the spread and 83% of the dollars wagered on the spread are on the Browns -1 vs. Falcons
86% of tickets on the spread and 76% of the dollars wagered on the spread are on the Cowboys -3 vs. Commanders
63% of tickets on the spread and 69% of the dollars wagered on the spread are on Raiders -2.5 vs. Broncos

71% of tickets on the spread are on Chiefs +1, but 67% of the dollars wagered on the spread are on Buccaneers -1.
78% of tickets on the spread are on Cardinals +1, but 55% of the dollars wagered on the spread are on Panthers -1.

[Oct 2, 2022 at 10:21 am ET · Tyler Sullivan]

Per Caesars Sportsbook: Josh Allen UNDER 1.5 passing TDs has twice as many tickets as any other prop wage. 

[Oct 2, 2022 at 10:18 am ET · Tyler Sullivan]

Continues to sound optimistic for CMC, but definitely keep an eye on his status. Panthers play in the late afternoon window, so have an insurance plan ready if things take a turn. 

[Oct 2, 2022 at 9:56 am ET · Tyler Sullivan]

It's not a good morning for Alvin Kamara fantasy owners. 

[Oct 2, 2022 at 9:42 am ET · Tyler Sullivan]

Interesting nugget from Caesars: UNDERs are hitting at 60% through Week 3, the highest since 1991.

[Oct 2, 2022 at 9:34 am ET · Tyler Sullivan]

If you have an open roster spot on your fantasy team, go check and see if Brian Robinson is available. The Commanders running back is expected to be activated after Week 4, according to the NFL Network. A miraculous comeback after Robinson was shot multiple times in an attempted robbery that occurred at the end of camp.

[Oct 2, 2022 at 9:20 am ET · Tyler Sullivan]

Looks like the weather is going to be a factor in Jaguars-Eagles. Should be the case for a lot of games in the northeast today. 

[Oct 2, 2022 at 9:18 am ET · Tyler Sullivan]

As New Orleans hobbles into their London game, their NFC South rivals are getting back to full strength. According to multiple reports, Chris Godwin, Russell Gage and Julio Jones are all expected to play today against the Chiefs. Tampa Bay is also getting Mike Evans back from his one-game suspension. 

[Oct 2, 2022 at 9:13 am ET · Tyler Sullivan]

Meanwhile, Caesars announced that a Nevada bettor placed a $50k bet on Saints ML on Friday. At +150, they'd be looking at a $75k win. 

[Oct 2, 2022 at 9:12 am ET · Tyler Sullivan]

Just under 10 minutes until kickoff for Saints-Vikings. According to Caesars Sportsbook, 84% of the bets are on Minnesota to cover.

[Oct 2, 2022 at 8:17 am ET · Kevin Steimle]

Alvin Kamara is inactive today. Huge blow for the Saints and fantasy owners. Mark Ingram should see the bulk of the work at running back now.