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Carlos Rodon gets his first taste of the Bay Area rivalry when he takes the mound for the San Francisco Giants against the Oakland A's on Tuesday in the first game of a two-game series at Oracle Park in San Francisco. Signed for $44 million in the offseason, Rodon (2-0, 1.06 ERA) has gotten off to a strong start to the season for the Giants (12-5). On Tuesday he squares off against Daulton Jefferies (1-2, 1.17). San Francisco is a -270 money-line favorite (risk $270 to win $100) in the latest MLB odds from Caesars Sportsbook, while Oakland is a +230 underdog. First pitch is set for 9:45 p.m. ET. 

The game is one of 15 on the MLB schedule on Tuesday. Elsewhere in the majors, the Mets and Cardinals (+105) collide in the second game of their three-game series at Busch, and the Rangers host the rival Astros (-115). Before locking in any MLB picks or parlays, be sure to check out the MLB predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times and it is off to a sizzling start to the 2022 season. It's on a 25-11 roll on top-rated MLB money-line picks through three weeks, returning almost $1,100 for $100 players. Anyone following it has seen huge returns.

Now, the model has locked in four confident MLB best bets for Tuesday. They all involve games at 6:35 p.m. ET or later, so there's still time to get these MLB picks in. If you successfully parlay the picks, you'd be looking at a payout of almost 12-1. You can see the model's MLB picks for Tuesday only at SportsLine. 

Top MLB picks today

After simulating every game 10,000 times, the model is taking Houston (-110) to beat Texas. The Astros have dominated the series against the Rangers recently. Since the start of the 2017 season, Houston is 56-31 against Texas. In the last 10 meetings, the Astros are 7-3.

In addition, the Astros are a much better team versus lefties than righties. Houston is 4-2 this season against southpaws and just 3-7 against righties. On Tuesday the Astros face lefty Taylor Hearn (0-1, 7.59 ERA), who gave up five runs on five hits and four walks in three innings against the Mariners in his last start.

How to make MLB picks and parlays for Tuesday

The model also locked in three other best bets for Tuesday, including a play on a big American League underdog. You can see the model's MLB Tuesday best bets and parlay only at SportsLine.

What MLB picks should you target for a payout of almost 12-1? And what underdog does the model like on Tuesday? Visit SportsLine now to see the MLB best bets from an advanced model that is on a 25-11 roll on top-rated MLB money-line picks through three weeks, and find out.