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The Chicago White Sox welcome the Detroit Tigers to Guaranteed Rate Field on Saturday. Chicago and Detroit face off in the third game of a four-game series over the weekend, with the Tigers on a hot streak. Detroit enters Saturday's game with six straight wins. In contrast, Chicago has dropped four of the last five, and the White Sox are aiming to right the ship.

Caesars Sportsbook lists Chicago as the -165 money-line favorite for this 2:10 p.m. ET first pitch. The total number of runs Vegas thinks will be scored, or the over-under, is 8.5 in the latest Tigers vs. White Sox odds. Before making any White Sox vs. Tigers picks, be sure to check out the latest MLB predictions and betting advice from the SportsLine Projection Model.

The SportsLine Projection Model simulates every MLB game 10,000 times, and it is 271-232 on top-rated MLB money-line picks since the start of the 2021 season, returning well over $500 for $100 players. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win it all last season. Anybody who has followed it has seen profitable returns.

Now, the model has set its sights on White Sox vs. Tigers, and just locked in its picks and MLB predictions. You can head to SportsLine now to see the model's picks. Here are several MLB odds and betting lines for Tigers vs. White Sox:

  • Tigers vs. White Sox money line: White Sox -165, Tigers +140
  • Tigers vs. White Sox over-under: 8.5 runs
  • Tigers vs. White Sox run line: White Sox -1.5 (+122)
  • DET: The Tigers are 21-22 in day games
  • CHI: The White Sox are 21-19 in day games
  • Tigers vs. White Sox picks: See picks at SportsLine

Why you should back the Tigers

The Tigers are playing well in July, posting a .727 OPS this month. Detroit's six-game winning streak paints an encouraging picture, and the Tigers have the second-most triples (16) in the American League this season. On the mound, Detroit will send 26-year-old left-hander Garrett Hill to the mound for his second career start, and he allowed only two hits and one earned run in his first outing against the Cleveland Guardians. 

When Hill exits, Detroit's bullpen is a clear strength. The Tigers rank in the top three of the American League in myriad categories, including wins above replacement, and Detroit's relief corps has a 3.04 ERA and a 45.0 percent ground ball rate. The White Sox also have notable flaws on offense, with Chicago ranking in the bottom tier of the American League in triples, home runs, stolen bases, walks and slugging percentage.

Why you should back the White Sox

Chicago's offense can be potent, ranking near the top of the American League in hits, batting average and strikeout avoidance. Keyed by former AL MVP and three-time All-Star Jose Abreu, the White Sox have strong depth in the lineup, and Chicago's offense is far more prolific than Detroit's offense. The Tigers currently rank in the bottom three of the American League in runs scored, hits, doubles, home runs, stolen bases, walks, on-base percentage, slugging percentage and OPS, illustrating the team's overall weakness at the plate. 

From there, Chicago can rely on Johnny Cueto to provide a strong baseline. The 36-year-old starting pitcher has a 3.30 ERA this season, walking only 2.7 batters per nine innings. Cueto, a two-time All-Star with a career 3.45 ERA and impressive overall pedigree, also boasts a 2.96 ERA in the last four starts and a 2.88 career ERA against Detroit.

How to make Tigers vs. White Sox picks

SportsLine's model is leaning under on the total, projecting 8.2 total runs. It also says one side of the money line has all the value. You can only get the model's MLB picks at SportsLine.

So who wins White Sox vs. Tigers? And which side has all the value? Visit SportsLine now to see which side you need to jump on, all from the model that has crushed its MLB picks, and find out.