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The Philadelphia 76ers will take on the Indiana Pacers at 7 p.m. ET Wednesday at Wells Fargo Center. Philadelphia is 22-14 overall and 15-5 at home, while Indiana is 21-17 overall and 8-10 on the road. The Sixers have won each of the last three matchups, including a 120-106 victory in late October.

Philadelphia is favored by 8 points in the latest 76ers vs. Pacers odds from Caesars Sportsbook, and the over/under is set at 233. Before entering any Pacers vs. 76ers picks, you'll want to see the NBA predictions from the model at SportsLine.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in profit for $100 players on its top-rated NBA picks over the past four-plus seasons. The model enters Week 12 of the 2022-23 NBA season on a stunning 38-13 roll on all top-rated NBA picks this season, returning almost $2,300. Anyone following it has seen huge returns.

Now, the model has set its sights on 76ers vs. Pacers. You can head to SportsLine to see its picks. Here are several NBA betting lines for Sixers vs. Pacers:

  • 76ers vs. Pacers spread: 76ers -8
  • 76ers vs. Pacers over/under: 233 points
  • 76ers vs. Pacers money line: Philadelphia -345, Indiana +270
  • 76ers vs. Pacers picks: See picks here

What you need to know about the Pacers

The Pacers were able to grind out a solid win over the Toronto Raptors on Monday, winning 122-114. The top scorers for Indiana were shooting guard Bennedict Mathurin (21 points) and small forward Buddy Hield (19 points).

It was the fourth straight win for Indiana, which is one short of matching its season-high. The Pacers are one of the most prolific and efficient 3-point shooting teams in the NBA, ranking fourth in made 3-pointers and eighth in 3-point percentage. Hield leads the league with 146 made threes, and he's one of three Pacers -- along with Tyrese Haliburton and Myles Turner -- shooting over 40% from beyond the arc.

What you need to know about the 76ers

Meanwhile, the New Orleans Pelicans typically have all the answers at home, but on Monday, Philadelphia proved too difficult a challenge. Philadelphia beat the Pelicans 120-111. Center Joel Embiid continued his habit of dropping crazy stat lines, posting a double-double on 42 points and 11 boards in addition to five assists.

While Indiana is one of the league's best 3-point shooting teams, Philadelphia is the NBA's best team at defending the long ball. It is limiting opponents to a league-best 33.4% from beyond the arc, which is a big reason why Philly has the league's No. 3 defensive rating. On offense, Embiid ranks second in the NBA with 33.5 points per game after leading all players with 30.6 PPG last season.

How to make Pacers vs. 76ers picks

The model has simulated 76ers vs. Pacers 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in well over 50% of simulations. You can only see the pick at SportsLine.

So who wins Pacers vs. Sixers? And which side of the spread hits in well over 50% of simulations? Visit SportsLine now to see which side of the spread you need to jump on, all from the model that has crushed its NBA picks, and find out.