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Eastern Conference foes collide when the Boston Celtics (49-30) go on the road to play the Chicago Bulls (45-33) in a primetime battle on Wednesday night. The Celtics are currently the second seed in the Eastern Conference and Chicago is the No. 6 seed. Robert Williams III (knee) is out for Boston, while Alex Caruso (back) is doubtful for the Bulls.

Tip-off is at 8 p.m. ET at the United Center. Boston is favored by seven points in the latest Celtics vs. Bulls odds from Caesars Sportsbook, while the over-under for total points scored is 224. Before locking in any Bulls vs. Celtics picks, be sure to see the NBA predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in profit for $100 players on its top-rated NBA picks over the past three-plus seasons. The model enters Week 25 of the 2021-22 NBA season on a stunning 84-54 roll on all top-rated NBA picks, returning over $2,400. Anyone following it has seen huge returns.

Now, the model has set its sights on Celtics vs. Bulls, and just locked in its picks and NBA predictions. You can head to SportsLine now to see the model's picks. Here are several NBA odds and betting lines for Bulls vs. Celtics:

  • Celtics vs. Bulls spread: Boston -7
  • Celtics vs. Bulls over-under: 224 points
  • Celtics vs. Bulls money line: Boston -270, Chicago +220
  • BOS: The Celtics are 4-0 ATS in their last 4 games following a straight-up win
  • CHI: The over is 5-0 in Chicago's last 5 games following a double-digit loss at home

Why the Celtics can cover

Guard Jaylen Brown has unique athleticism with the speed, quickness, and great high-flying ability to constantly attack the basket. Brown puts up 23.7 points, 6.1 rebounds, and 3.4 assists per game. The California product logged 30-plus points in five of his last eight games and Brown also shoots 36 percent from three. In his last contest, Brown registered 32 points, seven rebounds, five assists, and went 4-for-5 from downtown.

Guard Derrick White is an all-around player in the backcourt who can score inside and out, set up his teammates, and play solid defense. He logs 13.3 points, 3.5 rebounds, and five assists per game. The Colorado product scored 15-plus in three of his last five games. In the blowout win over the Washington Wizards, White added 17 points, five rebounds, three assists, and shot an efficient 6-for-7 from the field. 

Why the Bulls can cover

Forward DeMar DeRozan is a gifted offensive scorer, dominating from the mid-range and driving to consistently draw contact. DeRozan is ranked sixth in the NBA in points (28) to go along with 5.3 rebounds and five assists per game. He also averages eight free throws a game, shooting 87 percent from the charity stripe. On March 31, the five-time All-Star dropped 50 points, five rebounds and six assists. 

Center Nikola Vucevic is a top-tier rebounder, dominating the glass. Vucevic can score in the post at will and can knock down an open jumper if needed. The USC product averages 17.9 points, 11.2 rebounds and 3.3 assists per game. The 2011 first-round pick is tied for fourth in the league in double-doubles (44). On March 31, he finished with 22 points and 14 rebounds. 

How to make Bulls vs. Celtics picks

SportsLine's model is leaning over on the total, projecting 225 combined points. The model also says one side of the spread hits in nearly 60 percent of simulations. You can only see the model's Bulls vs. Celtics pick at SportsLine.

So who wins Celtics vs. Bulls? And which side of the spread hits in almost 60 percent of simulations? Visit SportsLine now to see which side of the Bulls vs. Celtics spread you need to jump on Wednesday, all from the model that has crushed its NBA picks, and find out.