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The Boston Celtics (44-18) are hosting the Cleveland Cavaliers (39-25) in a battle between Eastern Conference rivals. Cleveland has won both matchups thus far in the campaign, including a 114-113 overtime win on Nov. 2. Boston is currently sitting as the second seed in the conference, meanwhile, Cleveland is in fourth place.

Tip-off is scheduled for 7:30 p.m. ET at TD Garden in Boston. Caesars Sportsbook lists the Celtics as a 5-point favorite in the latest Cavaliers vs. Celtics odds, while the over/under for total points scored is set at 219. Before making any Celtics vs. Cavaliers picks, you'll want to see the NBA predictions and betting advice from the proven computer model at SportsLine.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in profit for $100 players on its top-rated NBA picks over the past four-plus seasons. The model enters Week 20 of the 2022-23 NBA season on a stunning 57-30 roll on all top-rated NBA picks this season, returning nearly $2,300. Anyone following it has seen huge returns.

Now, the model has set its sights on Cavaliers vs. Celtics and just locked in its picks and NBA predictions. You can head to SportsLine now to see the model's picks. Here are several NBA odds and betting lines for Celtics vs. Cavaliers:

  • Cavaliers vs. Celtics spread: Boston -5
  • Cavaliers vs. Celtics over/under: 219 points 
  • Cavaliers vs. Celtics money line: Boston -210, Cleveland +175
  • CLE: The Cavaliers are 5-1 ATS in their last six games following an ATS win
  • BOS: The Celtics are 4-0 ATS in their last four home games
  • Cavaliers vs. Celtics pick: See picks at SportsLine

Why the Cavaliers can cover

Guard Darius Garland does a great job drawing the defense out and creating passing lanes. Garland is a diverse scorer who excels at finishing with either hand and is averaging 21.9 points with 7.9 assists per game. He also shoots 42% from downtown. On Feb. 15, Garland dropped 27 points, six assists, and went a perfect 6-of-6 from 3-point land.

Forward Evan Mobley is an agile big man who has the quickness and verticality to rise over his defender but also owns a soft touch. The USC product has good timing as a shot blocker, and he logs 16 points, 8.8 rebounds, and 1.3 blocks per game. On Feb. 23, Mobley had 31 points and nine boards. 

Why the Celtics can cover

Forward Jayson Tatum is a three-level scorer who has an array of moves to get a bucket. Tatum utilizes his post game, perimeter jumper, and has the strength to finish through contact at the rim. The four-time All-Star is sixth in the NBA in points (30.1) with 8.7 rebounds and 4.7 assists per game. On Feb. 23, he totaled 31 points, 12 rebounds and seven assists.

Guard Jaylen Brown owns outstanding athleticism on both ends of the floor. Brown has the bounce to soar over defenders and has range on his jumpers. The two-time All-Star owns good lateral quickness and length to play aggressive defense on the perimeter. Brown averages 26.5 points, 7.0 rebounds and 3.2 assists per game. In his last outing, he finished with 26 points, three steals and four rebounds.

How to make Cavaliers vs. Celtics picks

SportsLine's model has simulated Celtics vs. Cavs is leaning Over on the total, projecting the teams to combine for 232 points. The model also says one side of the spread hits in nearly 60% of simulations. You can only get the pick at SportsLine.

So who wins Celtics vs. Cavaliers? And which side of the spread hits nearly 60% of the time? Visit SportsLine now to find out which side of the spread you need to jump on, all from the model that has crushed its NBA picks, and find out.