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The Indiana Pacers (2-1) will try to spring a big upset when they face the Boston Celtics (3-0) on Wednesday night. Indiana won its first two games of the season before losing to Chicago in a 112-105 final on Monday. Boston has won all three of its games, including a 126-107 blowout at Washington earlier this week. The Celtics have not won four straight games to open a season since 2009, when they won six straight games. 

Tipoff is set for 7:30 p.m. ET at TD Garden in Boston. The Celtics are favored by 11.5 points in the latest Celtics vs. Pacers odds, while the over/under is 234.5 points, per SportsLine consensus. Before entering any Pacers vs. Celtics picks, you'll want to see the NBA predictions from the model at SportsLine.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in profit for $100 players on its top-rated NBA picks over the past five seasons. The model enters Week 2 of the 2023-24 NBA season on a 77-41 roll on all top-rated NBA picks dating back to last season, returning nearly $3,000. Anyone following it has seen huge returns.

The model has set its sights on Celtics vs. Pacers. You can head to SportsLine to see its picks. Here are several NBA odds and betting lines for Pacers vs. Celtics:

  • Celtics vs. Pacers spread: Celtics -11.5
  • Celtics vs. Pacers over/under: 234.5 points
  • Celtics vs. Pacers money line: Celtics: -636, Pacers: +448
  • Celtics vs. Pacers picks: See picks here

Why the Celtics can cover

Boston is coming off its best performance of the season, cruising to a 126-107 road win at Washington. Jaylen Brown poured in 27 points in the first half, tying the franchise record with seven 3-pointers before intermission. The Celtics led 42-19 at the end of the first quarter, allowing them to rest some starters in the second half. 

Jayson Tatum added 33 points on Monday, while new addition Kristaps Porzingis finished with 15. Porzingis is averaging 20.7 points and 7.7 rebounds through his first three games with Boston, despite working his way back into top form after missing the FIBA World Cup this summer. The Celtics have won eight of their last nine home games against the Pacers and 15 of the last 19 meetings overall. Meanwhile, Indiana could be shorthanded as Tyrese Haliburton (ankle), Bennedict Mathurin (elbow) and Jalen Smith (knee) are all questionable.

Why the Pacers can cover

Indiana knows what it is like to blow out Washington, as the Pacers scored 143 points in a 23-point win over the Wizards in their season opener. They added a double-digit win at Cleveland last Saturday, holding the Cavaliers to just 12 points in the second quarter. Star point guard Haliburton leads Indiana with 20.0 points, 12.3 assists and 5.3 rebounds per game. 

Veteran center Myles Turner gives Indiana an elite paint presence, averaging a double-double with 17.0 points and 10.3 rebounds. The Celtics are coming off a blowout win, but they won their first two games of the season by single digits. They have only covered the spread once in their last five home games, and Indiana has covered in four of the last five meetings between these teams. See which team to pick here. 

How to make Pacers vs. Celtics picks

The model has simulated Celtics vs. Pacers 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in over 50% of simulations. You can only see the pick at SportsLine.

Who wins Pacers vs. Celtics, and which side of the spread hits over 50% of the time? Visit SportsLine now to see the picks, all from the model that is on a 77-41 roll on top-rated NBA picks, and find out.