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It's difficult to imagine Mexico needing more motivation to win the 2021 Concacaf Gold Cup title, as it enters as the defending champion and has captured the crown in four of the last six tournaments. El Tri has it, however, after star Hirving Lozano exited the Mexicans' group-stage opener with a head injury and will be unavailable for the remainder of the competition. Mexico continues on without Lozano when it faces Guatemala on Wednesday in the group stage of the 2021 Concacaf Gold Cup. The Mexicans finished with a 0-0 draw against Trinidad and Tobago on Saturday, while the Guatemalans suffered a 2-0 loss to El Salvador in its opening match a day later.

Kickoff is set for 9:30 p.m. ET in Dallas. Mexico is listed as the -4000 favorite (risk ($4,000 to win $100) on the money line in the latest Mexico vs. Guatemala odds at William Hill Sportsbook, while Guatemala is the +4500 underdog. The over-under for total goals scored is 3.5. Before making any Guatemala vs. Mexico picks or 2021 Concacaf Gold Cup predictions, you have to see what proven soccer insider Martin Green has to say.

After working in the sports betting industry for several years, Green became a professional sports writer and handicapper, and has covered the game worldwide. Since then, his expert soccer picks have been spot-on. Green has generated nearly $19,000 for $100 bettors since the 2017-18 season. He has his finger on the pulse of the game all over the globe.

Now, Green has taken an in-depth look at Mexico vs Guatemala. You can head to SportsLine now to see his Gold Cup picks. Here are the 2021 Concacaf Gold Cup betting odds and trends for Guatemala vs Mexico:

  • Mexico vs. Guatemala spread: Mexico -2.5 
  • Mexico vs. Guatemala over-under: 3.5 goals 
  • Mexico vs. Guatemala money line: Mexico -4000, Guatemala +4500, Draw +1000 
  • MEX: El Tri is riding a 12-game unbeaten streak in Gold Cup group-stage play 
  • GUA: Guatemala recorded seven wins and four draws in 11 matches across all competitions before losing their group-stage opener

Why you should back Mexico

Despite being kept off the scoresheet in their group-stage opener, El Tri continued their strong defensive play against Trinidad and Tobago by posting their fourth consecutive clean sheet and sixth in eight matches. They also have held their opponent without a shot on goal in each of their last three contests. In its last five meetings with Guatemala, Mexico has allowed a total of one goal while recording three wins and a pair of scoreless draws.

The most recent meeting took place on Sept. 30, when El Tri cruised to a 3-0 triumph on home soil in a friendly. Despite being without Lozano, Mexico still possesses some dangerous offensive weapons in Rogelio Funes Mori, who scored 15 goals in 31 games for Monterrey of Liga MX in 2020-21, and Porto's Jesus Corona, who recorded two goals and seven assists in league play last season. 

Why you should back Guatemala

Guatemala performed well in its 2-0 loss against El Salvador on Sunday despite learning it would compete in the tournament just two days earlier. Guatemala's defense came up with a strong effort, keeping its opponent off the scoreboard for the first 80 minutes before surrendering a pair of late goals. The goals were the first allowed by Guatemala in eight matches this year, as it posted clean sheets while recording five wins and a pair of draws in its first seven games of 2021.

Guatemala is due to pick it up offensively, as it has been held to fewer than two goals in four of its five matches since posting a 10-0 victory in a FIFA World Cup qualifier against Saint Vincent and the Grenadines in early June. It has produced a total of five goals in those five games, with Luis Martinez scoring two of them. The 29-year-old forward also was one of the 10 scorers in last month's rout, giving him tallies in three of Guatemala's last six contests.

How to make Mexico vs. Guatemala picks

Green has taken a close look at the Mexico vs. Guatemala matchup from all angles and is leaning under on the goal total. He also has revealed two additional best bets, including one with a plus-money payout. He's only sharing those expert picks at SportsLine.

So who wins Guatemala vs. Mexico? And where does all the betting value lie? Visit SportsLine now to see the best bets for Mexico vs. Guatemala, all from the soccer expert who has his finger on the pulse of the game all over the world, and find out.