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An intriguing midweek English Premier League matchup is on tap Wednesday as Manchester United host Tottenham in a top-five battle at Old Trafford. Both teams have been red-hot lately, with Tottenham (7-2-1) third in the EPL table and United (5-1-3) sitting fifth. Spurs are tied with reigning champion Manchester City on points but behind on goal differential, and both are four points off the pace of Arsenal. United trail the league leaders by 11 but are just three points behind fourth-place Chelsea, and they handed Arsenal their only loss of the season. They also beat Liverpool and have only lost to rival City in league play since putting a season-opening two-game losing streak behind them.    

Kickoff in Manchester, England is set for 3:15 p.m. ET. The latest Manchester United vs. Tottenham odds from Caesars Sportsbook list United as the +135 favorite (risk $100 to win $135), with Spurs the +195 underdog. A draw is priced at +235, and the over/under for total goals scored is set at 2.5. Before you lock in any Tottenham vs. Manchester United picks or English Premier League predictions, you need to see what SportsLine soccer insider Brandt Sutton has to say.

Sutton, a former collegiate soccer player, has been SportsLine's top soccer editor for nearly five years. He has followed soccer closely for much longer and factors in managerial tactics, projected lineups and past performances to make the most-informed decisions possible, keeping his finger on the pulse of the game all over the globe. 

Sutton has also been on a roll with his best bets, going 133-103-1 on his soccer picks in 2022, returning almost $1,700 for $100 bettors. 

Now, Sutton has broken down the Manchester United vs. Tottenham matchup from every angle and just locked in his picks and EPL predictions. You can head to SportsLine now to see his picks. Here are the betting lines and trends for Tottenham vs. Manchester United:

  • Man U vs. Tottenham spread: United -0.5 (+135)
  • Man U vs. Tottenham over/under: 2.5 goals 
  • Man U vs. Tottenham money line: United +135, Spurs +195, Draw +235 
  • MAN: The Red Devils haven't won four consecutive games against Spurs since 2009-10 
  • TOT: Spurs are 11-4-1 in their past 16 EPL matches, with a 35-12 goal advantage 
  • Man U vs. Tottenham picks: See picks here

Why you should back Manchester United

The Red Devils might be coming in off a draw, but they had plenty of chances against Newcastle, holding 63% possession and a 15-9 advantage in shots. The victories against Liverpool and Arsenal show how dangerous they are, and they are 5-1-1 in the past seven meetings with Spurs. United have conceded 15 league goals, but only four were scored at Old Trafford, where they are 10-6-2 in their past 18 EPL matches. Spurs have scored just seven of their 22 goals in road matches, and they have won twice in seven away from home in all competitions (2-3-2).  

Cristiano Ronaldo had four goals as United outscored Spurs 6-2 in their two meetings last season, and he could be in line for a rare start. The play of Marcus Rashford (three goals) might not allow that to transpire, but the legendary scorer is sure to play a role. Rashford, Antony (three goals), Jadon Sancho (two) and Bruno Fernandes (one) are all proven finishers, and Sunday's game was just the second time this season United have failed to score. They had eight goals over their previous three games and have allowed one or fewer in six of their past seven.

Why you should back Tottenham

Spurs have the clear edge in scoring, with Harry Kane and Son Heung-min leading an attack that has 22 goals. Kane scored for the fifth straight league match when he converted a penalty against Everton, and he is second in the league with nine goals. Son scored 23 last season and is starting to heat up, with five in his past six matches overall. Tottenham make the most of their shots and keep their goalkeeper out of trouble. They put 39& of their attempts on target, while opponents hit the net just 24% of the time, both marks the best in the league.  

That efficiency could be a major problem for United goalkeeper David de Gea, who has saved just 23 of the 38 shots he has faced (60.5&). United have conceded five more goals than Spurs, and Tottenham's Hugo Lloris has a 74.3 save percentage. 

How to make Tottenham vs. Manchester United picks

Sutton has analyzed the Manchester United vs. Tottenham match from all sides, and he is going Over on the goal total. He also has two other confident best bets, including a strong play on a goal scorer, and a full breakdown of the match. He's only sharing his Premier League picks and analysis here.

So who wins Tottenham vs. Manchester United? And where does all the betting value lie? Visit SportsLine now to see the best bets for Manchester United vs. Tottenham, all from the soccer expert who is up nearly $1,700 on his soccer picks in 2022, and find out.