| Free Agents | Pos. | Status |
| Livan Hernandez | SP/RH | |
| Mike MacDougal | RHP | |
| Scott Olsen | SP/LH | Re-signed ($1 mil, 1 yr) |
| Ron Villone | RP/LH | |
| Dmitri Young | 1B | |
| Arbitration-Eligible | Pos. | Status |
| Jason Bergmann | RP/RH | Re-signed ($750 k, 1 yr) |
| Brian Bruney | RP/RH | Traded from NYY |
| Sean Burnett | RP/LH | |
| Jesus Flores | C | Re-signed ($750 k, 1 yr) |
| Logan Kensing | RP/RH | Re-signed (minor league deal) |
| Wil Nieves | C | Re-signed ($700 k, 1 yr) |
| Pete Orr | INF | Re-signed (minor league deal) |
| Josh Willingham | LF | Re-signed ($4.6 mil, 1 yr) |
| Acquired | Pos. | Status |
| Miguel Batista | RP/RH | Signed (from SEA, minor league deal) |
| Eric Bruntlett | INF/OF | Signed (from PHI, minor league deal) |
| Matt Capps | RP/RH | Signed (from PIT, $3.5 mil, 1 yr) |
| Chris Duncan | LF | Signed (minor league deal) |
| Shawn Estes | SP/LH | Signed (minor league deal) |
| Eddie Guardado | RP/LH | Signed (from TEX, minor league deal) |
| Chuck James | SP/LH | Signed (minor league deal) |
| Adam Kennedy | 3B | Signed ($1.25 mil, 1 yr) |
| Jason Marquis | SP/RH | Signed (from COL, $15 mil, 2 yrs) |
| Kevin Mench | LF | Signed (minor league deal) |
| Jerry Owens | RF | Signed (minor league deal) |
| Joel Peralta | RP/RH | Signed (minor league deal) |
| Ivan Rodriguez | C | Signed (from TEX, $6 mil, 2 yrs) |
| Doug Slaten | RP/LH | Claimed off waivers from ARI |
| Ryan Speier | RP/RH | Signed (minor league deal) |
| Tyler Walker | RP/RH | Signed (minor league deal) |
| Josh Whitesell | 1B | Signed (from ARI, minor league deal) |
| Departed | Pos. | Status |
| Josh Bard | C | Signed with SEA (minor league deal) |
| Marco Estrada | RP/RH | Claimed off waivers by MIL |
| Austin Kearns | OF | Signed with CLE (minor league deal) |
| Wil Ledezma | RP/LH | Signed with PIT (minor league deal) |
| Jorge Padilla | OF | Signed by TOR (minor league deal) |
| Saul Rivera | RP/RH | Signed by CLE (minor league deal) |
| Zack Segovia | RP/RH | Signed by NYY (minor league deal) |
| Jorge Sosa | RP/RH | Signed by BOS (minor league deal) |
Joshington 
