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The San Diego State Aztecs (17-7) host the San Jose State Spartans (8-19) in a key Mountain West Conference matchup at 11 p.m. ET on Friday, Feb. 25 at Viejas Arena at Aztec Bowl. San Jose State has had a forgettable season, but did notch its first conference win against New Mexico on Sunday. San Diego State remains one of the top teams in the Mountain West, but did lose 58-57 in its last outing to Boise State.

San Diego State is favored by 22 points in the latest San Diego State vs. San Jose State odds from Caesars Sportsbook, and the over-under is set at 125. Before making any San Jose State vs. San Diego State picks, you need to see the college basketball predictions and betting advice from the red-hot computer simulation model at SportsLine.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of almost $2,000 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on San Diego State vs. San Jose State, and just locked in its picks and CBB predictions. You can head to SportsLine now to see the model's picks. Here are several college basketball odds and betting lines for San Diego State vs. San Jose State:

  • San Diego State vs. San Jose State spread: San Diego State -22
  • San Diego State vs. San Jose State over-under: 125 points

What you need to know about San Diego State

San Diego State was just a bucket short of a victory on Tuesday and fell 58-57 to the Boise State Broncos. Forward Nathan Mensah put forth a good effort for the losing side as he posted a double-double on 13 points and 11 boards in addition to three blocks.

The Aztecs are an elite defensive team, allowing only 57.1 points per game -- the second best mark in college basketball. Senior guard Matt Bradley is one of the conference's top players, with the senior guard averaging 16.8 points, 5.3 rebounds, and 2.7 assists per game. San Diego State is 13-11 against the spread in 2021-22.

What you need to know about San Jose State

Meanwhile, the Spartans strolled past the New Mexico Lobos with points to spare on Sunday, taking the game 71-55. SJSU can attribute much of their success to guard Omari Moore, who dropped a triple-double on 18 points, ten dimes, and ten rebounds.

The Spartans will have their hands full with San Diego State if they continue their trend of subpar defensive play. SJSU has allowed their opponents to shoot 46.60% from the floor on average, which is the 19th highest shooting percentage allowed in college basketball. San Jose State is 15-11 against the spread in 2021-22.

How to make San Diego State vs. San Jose State picks

The model has simulated San Diego State vs. San Jose State 10,000 times and the results are in. We can tell you that the model is leaning Over on the point total, and it's also generated a point-spread pick that is hitting in well over 60 percent of simulations. You can only see the model's SDSU vs. SJSU pick at SportsLine.

So who wins San Diego State vs. San Jose State? And which side of the spread hits well over 60 percent of the time? Visit SportsLine now to see which side of the San Diego State vs. San Jose State spread to jump on, all from the advanced model that is up almost $2,000 on its top-rated college basketball spread picks over the last five-plus years, and find out.