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The Iowa State Cyclones (20-11) and the No. 14 Texas Tech Red Raiders (23-8) are set to square off in a Big 12 Conference Tournament matchup at 9:30 p.m. ET on Thursday, March 10 at T-Mobile Center. Texas Tech is coming off an ugly 52-51 loss to Oklahoma State, but has won five of its last seven. Iowa State lost its last outing 75-68 to No. 3 Baylor.

Texas Tech is favored by 7.5 points in the latest Texas Tech vs. Iowa State odds from Caesars Sportsbook, and the over-under is set at 125.5. Before making any Iowa State vs. Texas Tech picks, you need to see the college basketball predictions and betting advice from the red-hot computer simulation model at SportsLine.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of almost $1,600 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Texas Tech vs. Iowa State, and just locked in its picks and CBB predictions. You can head to SportsLine now to see the model's picks. Here are several college basketball odds and betting lines for Texas Tech vs. Iowa State:

  • Texas Tech vs. Iowa State spread: Texas Tech -7.5
  • Texas Tech vs. Iowa State over-under: 126 points

What you need to know about Iowa State

Iowa State came up short against the Baylor Bears on Saturday, falling 75-68. The top scorer for Iowa State was guard Gabe Kalscheur (18 points).

Iowa State is one of the better defensive teams in the country. They come into this game boasting the 24th fewest points allowed per game in college basketball at 62.7. Senior guard Izaiah Brockington has had an outstanding season, averaging 17.5 points and 7.2 rebounds per game. Iowa State is 17-14 against the spread in 2021-22.

What you need to know about Texas Tech

Meanwhile, Texas Tech was just a bucket short of a win on Saturday and fell 52-51 to the Oklahoma State Cowboys. Texas Tech's defeat came about despite a quality game from forward Kevin Obanor, who posted a double-double on 16 points and ten boards.

Like Iowa State, Texas Tech is strong on the defensive end. The Red Raiders have been holding their opponents to a field goal percentage of 38.50%, which places them ninth in college basketball. Senior forward Bryson Williams leads the way for Texas Tech, averaging 14 points and 4.3 rebounds per game. Texas Tech is 20-11 against the spread in 2021-22.

How to make Texas Tech vs. Iowa State picks

The model has simulated Texas Tech vs. Iowa State 10,000 times and the results are in. We can tell you that the model is leaning Over on the point total, and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You can only see the model's Iowa State vs. Texas Tech pick at SportsLine.

So who wins Texas Tech vs. Iowa State? And which side of the spread hits well over 50 percent of the time? Visit SportsLine now to see which side of the Iowa State vs. Texas Tech spread to jump on, all from the advanced model that is up almost $1,600 on its top-rated college basketball spread picks over the last five-plus years, and find out.