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An ACC battle is on tap between the Clemson Tigers and the Virginia Tech Hokies at 7 p.m. ET Wednesday at Barclays Center. Clemson is 17-15 while Virginia Tech is 19-12. Virginia Tech has won three out of the last four matchups but Clemson prevailed 63-59 in a matchup this past Saturday.

The Hokies are favored by five points in the latest Virginia Tech vs. Clemson odds from Caesars Sportsbook, and the over-under is set at 130. Before entering any Clemson vs. Virginia Tech picks, you'll want to see the college basketball predictions from the model at SportsLine.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of almost $1,600 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Virginia Tech vs. Clemson. You can head to SportsLine to see its picks. Here are several college basketball odds for Clemson vs. Virginia Tech:

  • Virginia Tech vs. Clemson spread: Virginia Tech -5
  • Virginia Tech vs. Clemson over-under: 130 points

What you need to know about Clemson

The Tigers earned some postseason bragging rights after a successful outing on Tuesday as they managed a 70-64 victory over the NC State Wolfpack. Clemson can attribute much of its success to forward PJ Hall, who posted a double-double on 18 points and 10 rebounds along with four blocks.

It was the fifth straight win for the Tigers with one of those victories coming against Virginia Tech on March 5. In that game, Clemson overcame a second-half deficit thanks to strong play from its bench which contributed 41 of the team's 63 points. Hall led the way with a dozen points off the bench, although he'll want to be more careful with the ball this time around as he also committed five turnovers.

What you need to know about Virginia Tech

Virginia Tech is out to make up for these teams' contest this past Saturday. Guard Nahiem Alleyne put forth a good effort for the losing side as he shot 5-for-10 from downtown and finished with 17 points and five boards. Justyn Mutts (15 points) was the only other Virginia Tech player in double-figures.

Virginia Tech is one of the best defensive teams in the nation, holding opponents to 61.3 points per game which ranks 16th in Division I. The team is nearly unbeaten when it holds an opponent to 58 points or fewer, sporting an 11-1 record. However, when it allows 59 points or more, the Hokies are just 8-11.

How to make Clemson vs. Virginia Tech picks

The model has simulated Virginia Tech vs. Clemson 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins Clemson vs. Virginia Tech? And which side covers well over 50 percent of the time? Visit SportsLine now to find out, all from the model that has crushed its college basketball picks.