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The No. 18 Notre Dame Fighting Irish will try to win their ninth straight game in their rivalry with the Boston College Eagles on Saturday afternoon. Notre Dame has won four straight games this season, but it barely snuck past Navy in a 35-32 final last week. Boston College is coming off a huge upset win at then-No. 16 NC State as an 18-point underdog.

Kickoff is set for 2:30 p.m. ET. The Fighting Irish are currently listed as 21-point favorites in the latest Notre Dame vs. Boston College odds from Caesars Sportsbook, while the over/under for total points scored is 42.5. Before making any Boston College vs. Notre Dame picks, you'll want to see the college football predictions and betting advice from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Notre Dame vs. Boston College and just locked in its picks and CFB predictions. You can head to SportsLine now to see the model's picks. Here are several college football odds and betting lines for Notre Dame vs. Boston College:

  • Notre Dame vs. Boston College spread: Notre Dame -21
  • Notre Dame vs. Boston College over/under: 42.5 points
  • Notre Dame vs. Boston College money line: Notre Dame -1700, Boston College +950
  • Notre Dame vs. Boston College picks: See picks here

Why Notre Dame can cover

Notre Dame got off to a slow and disappointing start under first-year head coach Marcus Freeman, but the Fighting Irish have bounced back with a four-game winning streak. Their offense has been fantastic during the recent stretch, scoring at least 35 points in all four games. Quarterback Drew Pyne accounted for five total touchdowns against Navy last week-he has completed 63.1% of his passes for 1,547 yards and 18 touchdowns this season.

The Fighting Irish have won eight straight games in this rivalry, scoring at least 40 points in each of the last three matchups, winning those games by two-plus touchdowns. Boston College is coming off its first win over a ranked team in eight years, and it is unlikely that the Eagles add another one on Saturday. They have only covered the spread three times in their last 12 games, including just once in their last five road games. 

Why Boston College can cover

Boston College has not given up on its season, despite losing five games in a six-game stretch from the end of September to the beginning of November. The Eagles snapped their four-game losing streak with a 21-20 win at then-No. 16 NC State last week. They were 18-point underdogs in that matchup, but quarterback Emmett Morehead completed a touchdown pass with 14 seconds remaining to give his team the win. 

Morehead was making just his second career start, so he has some confidence and momentum heading into this game. It was Boston College's first win over a top 25 team in eight years. Morehead completed 29 of 48 passes for 330 yards and three touchdowns, providing the Eagles with a spark that they desperately needed. 

How to make Notre Dame vs. Boston College picks

The model has simulated Boston College vs. Notre Dame 10,000 times and the results are in. The model is leaning Over on the point total, and it's also generated a point-spread pick that is hitting in more than 50% of simulations. You can only see the model's pick at SportsLine.

So who wins Notre Dame vs. Boston College? And which side of the spread hits in more than 50% of simulations? Visit SportsLine now to see which side of the Boston College vs. Notre Dame spread you need to jump on Saturday, all from the model that has crushed its college football picks, and find out.