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The Boston Red Sox will try to reverse their late-summer slide when they face the rival New York Yankees on Wednesday in the final game of a three-game series at Yankee Stadium in the Bronx. The Red Sox (69-53) are just 6-13 since July 29 and have dropped from first place in the AL East to third place in the wild-card chase. Meanwhile the Yankees (68-52) have won five in a row and swept a doubleheader against the Red Sox on Tuesday. First pitch on Wednesday is 7:05 p.m. ET. The Yankees are -111 money-line favorites in the latest MLB odds from Caesars Sportsbook, while the Red Sox are +101 underdogs. 

The game is one of 15 on Wednesday's MLB schedule. Other matchups include AL Cy Young contender Lance Lynn and the White Sox facing Oakland and AL MVP favorite Shohei Ohtani taking the mound for the Angels against Detroit. Before making any MLB picks or predictions on those games or others, you need to see what the SportsLine Projection Model has to say.

This model, which simulates every pitch of every game 10,000 times, is 158-132 on top-rated MLB money-line picks through 20 weeks in the 2021 season, returning over $200. It also had a banner 2019 season, the league's last full schedule, returning more than $1,400 on its top-rated money-line and run-line picks. Anyone following it has seen some huge returns.

Now, the model has crunched the numbers for Wednesday's MLB schedule and posted its best bets. Successfully parlaying these four MLB picks would return more than 8-1. Head to SportsLine to see the picks.

Top MLB picks for Wednesday, Aug. 18

After simulating every game 10,000 times, the model is high on the Angels (-130) defeating Detroit. On Tuesday Los Angeles was playing in its third game in three days across three different cities and still beat the Tigers 8-2. The Angels broke the game open with a six-run ninth, highlighted by a grand slam from Jo Adell.

Los Angeles enters Wednesday's game with a big pitching edge. Ohtani is 4-0 in his last five starts, allowing just six runs and 20 hits while striking out 29 and walking just four. Also, the Angels rank 10th in the majors in OPS against left-handed pitchers (.754) and face southpaw Tarik Skubal (8-10) on Wednesday. 

How to make MLB predictions, parlays for Wednesday

The model has locked in three other MLB best bets, including one on a surprising underdog. You can see its best bets only at SportsLine.

So which MLB picks should you make on Wednesday for a shot at an 8-1 return? And which underdog do you need to be all over? Visit SportsLine now to see Wednesday's MLB picks, all from the projection model that's 158-132 on top-rated money-line picks in 2021, and find out.