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The Chicago White Sox will look to stay alive when they take on the visiting Houston Astros in Game 3 of their American League Division Series matchup on Sunday night. The White Sox (93-69), who won the AL Central by 13 games over Cleveland, have been outscored 15-5 in dropping the first two games of the series. The Astros (95-67), who won the AL West by five games over Seattle, have won four in a row and six of seven overall. Houston won the season series between the teams, 5-2.

First pitch from Guaranteed Rate Field in Chicago is set for 8:07 p.m. ET. The Astros lead the all-time series 40-39, although the White Sox own a 4-2 edge in the postseason. Chicago is a -121 favorite (risk $121 to win $100) on the money line in the latest Astros vs. White Sox odds from Caesars Sportsbook, while the over-under for total runs scored is 8.5. Before making any White Sox vs. Astros picks, be sure to see the MLB playoff predictions and betting advice from SportsLine's proven model.

This model, which simulates every game 10,000 times, enters the 2021 MLB playoffs with a 206-173 record on top-rated MLB money-line picks, returning well over $800. It also had a banner 2019 season, the league's last full schedule, returning more than $1,400 on its top-rated money-line and run-line MLB picks. Anyone following it has seen some huge returns. 

Now, the model has set its sights on White Sox vs. Astros and revealed its MLB playoff 2021 picks and analysis. You can head to SportsLine now to see the picks. Here are several MLB playoffs odds and trends for Astros vs. White Sox:

  • Astros vs. White Sox money line: Houston +110, Chicago -121
  • Astros vs. White Sox run line: Chicago -1.5 (+170)
  • Astros vs. White Sox over-under: 8.5 runs
  • HOU: The Astros are 5-1 in their last six playoff games
  • CHW: The White Sox are 6-1 in their last seven games as a favorite

Why you should back the White Sox

Chicago has its back to the wall, but has the offense to turn the series around. First baseman Jose Abreu, who led the White Sox with 30 homers this year, is hitting .500 in the series, going 4-for-8. He was a .261 hitter this season with 117 RBIs and 86 runs scored. In 42 career games against the Astros, Abreu has a .255 average with 10 doubles, six homers and 21 RBIs.

Center fielder Luis Robert is also off to a solid start to the postseason. Robert was 3-for-4 with an RBI and a walk in Game 2, and is 5-for 7 in the series. In 68 regular-season games this season, Robert batted .338 with 13 homers, 43 RBIs and 42 runs scored. He is 6-for-9 with three walks in his last three games.

Why you should back the Astros

Houston will send right-hander Luis Garcia (11-8, 3.30 ERA) to the mound. Although he is just 1-1 in his last three starts, he has allowed just four total earned runs in that span. He allowed three earned runs in five innings in his last outing, a 7-0 loss to the Tampa Bay Rays on Sept. 29. His start prior, he blanked the Angels over six innings of a 9-5 12-inning win over the Los Angeles Angels on Sept. 22. In that game, Garcia allowed just three hits, three walks and struck out one. 

Shortstop Carlos Correa has been red hot this series, going 3-for-6 with a double and two RBIs. He was 2-for-3 in Game 1. For the season, Correa batted .279 with 26 homers, 92 RBIs and 104 runs scored. In seven games against the White Sox this season, he has three extra-base hits, including a pair of home runs.

How to make White Sox vs. Astros picks

The model is leaning over on the total, projecting 9.6 combined runs. It also says one side of the money line hits in almost 60 percent of simulations. You can only get that pick at SportsLine. 

So who wins Astros vs. White Sox? And which side of the money line hits nearly 60 percent of the time? Visit SportsLine now to find out which side of White Sox vs. Astros you need to jump on, all from the model that has crushed it MLB picks, and find out.