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An American League showdown features the Houston Astros (40-25) hosting the Chicago White Sox (31-32) in a primetime battle on Sunday Night Baseball. The Astros sit in first place in the AL West standings. Meanwhile, Chicago is currently in third place in the AL Central. Michael Kopech (2-2, 1.92 ERA) gets the start for Chicago, while Cristian Javier (3-3, 3.20 ERA) takes the mound for Houston.

First pitch is set for 7:08 p.m. ET. Houston is the -150 money-line favorite (risk $150 to win $100) in the latest White Sox vs. Astros odds from Caesars Sportsbook, while Chicago is a +130 underdog. The over-under for total runs scored is 7.5. Before making any Astros vs. White Sox picks, you need to see the MLB predictions and betting advice from SportsLine's advanced computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times and it is off to a strong start to the 2022 season. It's on a 55-42 roll on top-rated MLB money-line picks through 10 weeks, returning over $600 for $100 players. Anyone following it has seen huge returns.

Now, the model has set its sights on White Sox vs. Astros, and just locked in its picks and MLB predictions. You can head to SportsLine now to see the model's picks. Here are several MLB odds and betting lines for Astros vs. White Sox:

  • White Sox vs. Astros money-line: Houston -150,  Chicago +130
  • White Sox vs. Astros run-line: Chicago +1.5 (-160)
  • White Sox vs. Astros over-under: 7.5 runs
  • White Sox vs. Astros tickets: See tickets at StubHub
  • CHW: The White Sox are 5-1 in their last six road games
  • HOU: The Astros are 6-0 in their last six Sunday games

Why you should back the Astros

Designated hitter Michael Brantley has a very good batter's eye with excellent patience and solid speed. Brantley is athletic and constantly produces runs for the Astros. The five-time All-Star is batting .295 with five home runs and 25 RBIs. On June 17, he went 2-for-5 with a grand slam. 

Second baseman Jose Altuve has some serious pop in his swing with great bat speed and control. Despite being undersized, Altuve plays big on both sides of the game. The seven-time All-Star is batting .274 with 12 home runs and 23 RBIs. In his last contest, he went 2-for-4 with two singles. 

Why you should back the White Sox

Center fielder Luis Robert is an all-around athletic player for Chicago. Robert is quick and agile in the outfield, allowing him to cover a lot of ground. He knows how to make consistent contact and get on base. The 24-year-old has a batting average of .290 along with six home runs and 28 RBIs. In his last outing, Robert went 3-for-5 with a double and four RBIs. 

Outfielder Andrew Vaughn has power, precision, and patience when he is at the plate. Vaughn owns a compact swing that drives the ball into any gap on the diamond. The 24-year-old is able to work into deep counts until he sees a pitch he likes. Vaughn is ninth in the MLB batting average (.322) with six home runs and 29 RBIs.

How to make Astros vs. White Sox picks 

SportsLine's model is leaning over on the total, projecting 8.6 combined runs. It also says one side of the money line has all the value. You can only get the model's MLB picks at SportsLine.

So who wins White Sox vs. Astros? And which side has all the value? Visit SportsLine now to see which side you need to jump on, all from the model that has crushed its MLB picks, and find out.