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Madison Square Garden hosts a Sunday afternoon matchup between the Philadelphia 76ers and the New York Knicks. Philadelphia is one of the top teams in the Eastern Conference, posting a 36-23 overall record this season. The 76ers are 20-10 on the road, while New York is 13-18 at home and 25-35 overall. 

Tip-off is at 1 p.m. ET in New York. Caesars Sportsbook lists the 76ers as eight-point road favorites, while the over-under, or total number of points Vegas thinks will be scored, is 219 in the latest 76ers vs. Knicks odds. Before you make any Knicks vs. 76ers picks, be sure to see the NBA predictions and betting advice from SportsLine's proven computer model. 

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in profit for $100 players on its top-rated NBA picks over the past three-plus seasons. The model enters Week 18 of the 2021-22 NBA season on a stunning 69-41 roll on all top-rated NBA picks, returning almost $2,300. Anyone following it has seen huge returns.

Now, the model has set its sights on 76ers vs. Knicks, and just locked in its picks and NBA predictions. You can head to SportsLine now to see the model's picks. Now, here are several NBA odds and betting lines for Knicks vs. 76ers:

  • 76ers vs. Knicks spread: 76ers -8
  • 76ers vs. Knicks over-under: 219 points
  • 76ers vs. Knicks money line: 76ers -360, Knicks +285
  • PHI: The 76ers are 16-18 against the spread in conference games
  • NYK: The Knicks are 16-21 against the spread in conference games

Why the 76ers can cover

Philadelphia's offense is dangerous and effective, scoring more than 1.11 points per possession in 2021-22. However, the 76ers have an appetizing defensive matchup against the Knicks that could swing the game. Philadelphia is No. 7 in the NBA in points allowed (105.9 per game), and the 76ers are in the top 10 of the league in field goal percentage allowed (45.1 percent), 3-point percentage allowed (33.7 percent), assists allowed (23.1 per game), and blocked shots (5.5 per game). 

The 76ers are also above-average in free throw prevention and steal creation, with New York falling short in several offensive categories. The Knicks are dead-last in the NBA in points in the paint, averaging only 40.7 per game, and New York is No. 27 or worse in field goal percentage, 3-point percentage, assists, and points per game.

Why the Knicks can cover

New York's defense has solid advantages in this matchup. The Knicks are No. 3 in the NBA points allowed in the paint, giving up only 43 per game, and New York is No. 6 in field goal percentage defense at 44.5 percent. Opponents are shooting only 52.1 percent on two-point attempts against the Knicks, and New York is in the top 10 in second-chance points allowed (12.7 per game) and blocked shots (5.0 per game). The Knicks are securing 73.1 percent of available rebounds on the defensive glass, and Philadelphia is the NBA's worst offensive rebounding team. 

The 76ers are grabbing only 24.2 percent of their own missed shots, and Philadelphia is also No. 27 in second-chance points. Philadelphia is also just No. 28 in the NBA in 3-pointers per game and No. 23 in the league in assists per game. New York isn't dynamic on offense, but the Knicks do rank in the top 10 of the league in offensive rebound rate, second-chance points, 3-pointers per game, and free throw attempts per game.

How to make Knicks vs. 76ers picks

SportsLine's model is leaning under on the total, projecting 216 combined points. The model also says one side of the spread hits in well over 50 percent of simulations. You can only see the model's pick at SportsLine.

So who wins 76ers vs. Knicks? And which side of the spread hits well over 50 percent of the time? Visit SportsLine now to find out which side of the spread you need to jump on Sunday, all from the model that has crushed its NBA picks, and find out.