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The Los Angeles Lakers (31-41) host the Philadelphia 76ers (44-27) in a cross-conference battle on Wednesday night. Philadelphia has won 10 of its last 14 games, while Los Angeles is 5-13 in its last 18 contests. The 76ers have dominated this series in recent years, winning eight of their last 10 meetings against the Lakers. 

Tip-off from Crypto.com Arena is at 10 p.m. ET. Philadelphia is favored by 9.5-points in the latest Lakers vs. 76ers odds from Caesars Sportsbook, while the over-under for total points scored is set at 226.5. Before entering any 76ers vs. Lakers picks, you'll want to see the NBA predictions from the proven computer model at SportsLine.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in profit for $100 players on its top-rated NBA picks over the past three-plus seasons. The model enters Week 22 of the 2021-22 NBA season on a stunning 79-49 roll on all top-rated NBA picks, returning over $2,400. Anyone following it has seen huge returns.

Now, the model has set its sights on Lakers vs. 76ers. You can head to SportsLine to see its picks. Here are several NBA betting lines for Lakers vs. 76ers:

  • Lakers vs. 76ers spread: Lakers +9.5
  • Lakers vs. 76ers over-under: 226.5 points
  • Lakers vs. 76ers money line: Lakers +360, 76ers -475

What you need to know about the Lakers

Los Angeles strolled past the Cleveland Cavaliers with points to spare on Monday, taking the contest 131-120. It was another big night for LeBron James, who dropped a triple-double with 38 points, 12 dimes and 11 boards. James has now scored 30 or more points in six of his last seven games, which includes a 50-point outburst against the Wizards on March 11. However, James (knee) has been ruled out for Wednesday's game against Philadelphia.

The Lakers are averaging 111.5 points per game this season, the 11th-best mark in the NBA. Defensively, Los Angeles is giving up 114.1 points per game, which ranks 26th in the league. The Lakers have lost 13 of their last 18 games, and they're 4-10 against the spread in their last 14 contests. 

What you need to know about the 76ers

Center Joel Embiid is a force for the 76ers, causing havoc on both ends of the floor. Embiid's offensive skill set is superb, scoring from all over the floor. The five-time All-Star selection is second in the NBA in points (29.8) and seventh in rebounds (11.3) per game. Embiid can bruise his way through defenders but can knock it down from the perimeter. He shoots 36 percent from beyond the arc. On March 16, Embiid produced 35 points, 17 rebounds and five assists. 

Forward Tobias Harris is another good offensive option for the 76ers. Harris is a three-level scorer with a smooth jumper. The Tennessee product logs 17.6 points, seven rebounds, and shoots 35 percent from downtown. The 2011 first-round pick has scored 20-plus in 21 games thus far. On March 13, Harris had 26 points, nine rebounds, and went 3-for-5 from 3-point range. 

How to make 76ers vs. Lakers picks

The model has simulated Lakers vs. 76ers 10,000 times and the results are in. The model is leaning under the total, and it's also generated a point-spread pick that is hitting in well over 60 percent of simulations. You can only see the pick at SportsLine.

So who wins Lakers vs. 76ers? And which side of the spread hits well over 60 percent of the time? Visit SportsLine now to see which side of the spread you need to jump on, all from the model that has crushed its NBA picks, and find out.