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The San Antonio Spurs will take on the Oklahoma City Thunder at 8 p.m. ET on Wednesday at Chesapeake Energy Arena. Oklahoma City is 12-19 overall and 4-10 at home, while the Spurs are 16-11 overall and 9-3 on the road. The Spurs won the first meeting of the season, 112-102 on Jan.12. Oklahoma City is favored by two-points in the latest Thunder vs. Spurs odds from William Hill Sportsbook, and the over-under is set at 216. Before entering any Spurs vs. Thunder picks, you'll want to see the NBA predictions from the advanced computer model at SportsLine.

The SportsLine Projection Model simulates every NBA game 10,000 times, and it returned over $5,000 in profit on its top-rated NBA picks last season. The model is also up almost $8,700 on top-rated NBA picks over the past two-plus seasons. Dating back to last season, it enters Week 10 of the 2020-21 NBA schedule on a stunning 85-49 roll on top-rated NBA picks against the spread. Anybody who has followed it has seen huge returns.

Now, the model has set its sights on Thunder vs. Spurs. You can head to SportsLine to see its picks. Here are several NBA betting lines for Thunder vs. Spurs:

  • Thunder vs. Spurs spread: Thunder -2
  • Thunder vs. Spurs over-under: 216 points

What you need to know about the Thunder

The Thunder were dismantled by the Miami Heat on Monday, 108-94 at home. OKC has lost four of its past five games. The Thunder were done in by a 15-0 Heat run to open the fourth quarter. Shai Gilgeous-Alexander was 10-of-15 from the field, 2-of-3 from three-point range and 5-of-6 on free throws to total 27 points.

Gilgeous-Alexander is averaging 22.6 points per game on 50.0 percent shooting from the field. Darius Bazley had 13 points and five rebounds on Monday. The Thunder have a 19-25 record vs. the Spurs during their Oklahoma City era.   

What you need to know about the Spurs

San Antonio didn't have too much trouble with the Charlotte Hornets in its most recent game on Feb. 14, a 122-110 win. The Spurs had their next four games postponed due to the league's health and safety protocols. They had won five of six games before the postponements. Against Charlotte, the Spurs scored 47 points in the second quarter, the most in a single quarter in team history since 1987. 

LaMarcus Aldridge (hip) is questionable for Wednesday's game. DeMar DeRozan (personal) is out. Derrick White, Rudy Gay and Keldon Johnson will all miss Wednesday's game due to health and safety protocols. 

How to make Spurs vs. Thunder picks

The model has simulated Thunder vs. Spurs 10,000 times and the results are in. We can tell you that the model is leaning over, and it's also generated a point-spread pick that is hitting in over 60 percent of simulations. You can only see the pick at SportsLine.

So who wins Spurs vs. Thunder? And which side of the spread hits in over 60 percent of simulations? Visit SportsLine now to see which side of the Spurs vs. Thunder spread to jump on Wednesday, all from the model that is on an incredible 85-49 roll.